Molecular Medicine Reports 2015-11-01

Synergistic topical application of salt-processed Phellodendron amurense and Sanguisorba officinalis Linne alleviates atopic dermatitis symptoms by reducing levels of immunoglobulin E and pro-inflammatory cytokines in NC/Nga mice.

Sunmin Park, Da Sol Kim, Suna Kang, Bae Keun Shin

文献索引:Mol. Med. Report. 12 , 7657-64, (2015)

全文:HTML全文

摘要

Atopic dermatitis is a chronic inflammatory skin disease, and salt-processed Phellodendron amurense (CPE) and Sanguisorba officinalis Linne (SOE) are widely used as anti-inflammatory agents in Asia. Therefore, the present study investigated the efficacy of CPE, SOE, and CPE+SOE in the treatment of atopic dermatitis-like symptoms in mice. Following topical application of 1,3‑butylen glycol (control), 30% CPE, 30% SOE, 15% CPE+15% SOE or 0.1% hydrocortisone (HC) on the atopic dermatitis‑like skin lesions of 2,4-dinitrochlorobenzene‑treated NC/Nga mice for 5 weeks, the severity of clinical atopic dermatitis, mast cell infiltration, serum expression levels of immunoglobulin (Ig)E, IgG1, interleukin (IL)-4 and interferon (IFN)-γ, and cytokine expression in the dorsal skin were measured. Compared with the control group, treatment with CPE alleviated the clinical severity of the AD symptoms, with decreased numbers of mast cells, decreased expression levels of serum tumor necrosis factor (TNF)‑α, IL‑4 and IFN‑γ, and decreased expression levels of inflammatory cytokines in the dorsal lesions. Treatment with SOE did not reduce these expression levels, however, the serum expression levels of IgE and IgG1 were suppressed to similar levels as those in the CPE group. Furthermore, synergistic treatment with CPE and SOE relieved the clinical severity of atopic dermatitis, reduced the serum expression levels of IgE, IgG1, TNF‑α, IL‑4 and IFN‑γ, and suppressed the mRNA expression levels of TNF‑α, IL‑4, IL‑13, and IFN‑γ in the dorsal skin lesions. Treatment with CPE+SOE was superior to treatment with HC alone for reducing dermal thickness and suppressing the production of several cytokines. Therefore, combined treatment with CPE and SOE may be an effective alternative intervention for the management of atopic dermatitis.


相关化合物

  • 氯仿
  • 甲醛
  • 1-氯-2,4-二硝基苯
  • 盐酸黄连素水合物
  • 苯酚
  • 苏木精
  • 溴甲酚绿
  • 盐酸黄连素; 盐酸...
  • 赛拉嗪
  • 丁酸氢化可的松

相关文献:

A survey of the interactome of Kaposi's sarcoma-associated herpesvirus ORF45 revealed its binding to viral ORF33 and cellular USP7, resulting in stabilization of ORF33 that is required for production of progeny viruses.

2015-05-01

[J. Virol. 89(9) , 4918-31, (2015)]

Aqueous-core PEG-coated PLA nanocapsules for an efficient entrapment of water soluble anticancer drugs and a smart therapeutic response.

2015-01-01

[Eur. J. Pharm. Biopharm. 89 , 30-9, (2015)]

SSX2 is a novel DNA-binding protein that antagonizes polycomb group body formation and gene repression.

2015-01-01

[Nucleic Acids Res. 42(18) , 11433-46, (2014)]

The dynamics of giant unilamellar vesicle oxidation probed by morphological transitions.

2014-10-01

[Biochim. Biophys. Acta 1838(10) , 2615-24, (2014)]

The dual FAAH/MAGL inhibitor JZL195 has enhanced effects on endocannabinoid transmission and motor behavior in rats as compared to those of the MAGL inhibitor JZL184.

2014-09-01

[Pharmacol. Biochem. Behav. 124 , 153-9, (2014)]

更多文献...