Macromolecular Bioscience 2015-03-01

Poly(anhydride-ester) and poly(N-vinyl-2-pyrrolidone) blends: salicylic acid-releasing blends with hydrogel-like properties that reduce inflammation.

Michelle A Ouimet, Renata Fogaça, Sabrina S Snyder, Sameer Sathaye, Luiz H Catalani, Darrin J Pochan, Kathryn E Uhrich

文献索引：Macromol. Biosci. 15(3) , 342-50, (2015)

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摘要

Polymers such as poly(N-vinyl-2-pyrrolidone) (PVP) have been used to prepare hydrogels for wound dressing applications but are not inherently bioactive. For enhanced healing, PVP was blended with salicylic acid-based poly(anhydride-esters) (SAPAE) and shown to exhibit hydrogel properties upon swelling. In vitro release studies demonstrated that the chemically incorporated drug (SA) was released from the polymer blends over 3-4 d in contrast to 3 h, and that blends of higher PVP content displayed greater swelling values and faster SA release. The polymer blends significantly the inflammatory cytokine, TNF-α, in vitro without negative effects. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

相关化合物

  • 氯仿
  • 三光气
  • 二氯甲烷
  • 四氢呋喃
  • 水杨酸
  • 二甲基亚砜
  • 己二酰氯
  • L-谷氨酰胺
  • 吡啶
  • 三乙胺

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