The nuclear receptor nr4a1 controls CD8 T cell development through transcriptional suppression of runx3.
Heba N Nowyhed, Tridu R Huynh, Amy Blatchley, Runpei Wu, Graham D Thomas, Catherine C Hedrick
文献索引:Sci. Rep. 5 , 9059, (2015)
全文:HTML全文
摘要
The NR4A nuclear receptor family member Nr4a1 is strongly induced in thymocytes undergoing selection, and has been shown to control the development of Treg cells; however the role of Nr4a1 in CD8(+) T cells remains undefined. Here we report a novel role for Nr4a1 in regulating the development and frequency of CD8(+) T cells through direct transcriptional control of Runx3. We discovered that Nr4a1 recruits the corepressor, CoREST to suppress Runx3 expression in CD8(+) T cells. Loss of Nr4a1 results in increased Runx3 expression in thymocytes which consequently causes a 2-fold increase in the frequency and total number of intrathymic and peripheral CD8(+) T cells. Our findings establish Nr4a1 as a novel and critical player in the regulation of CD8 T cell development through the direct suppression of Runx3.
相关化合物
相关文献:
2014-12-16
[Nucleic Acids Res. 42(22) , 14022-30, (2014)]
2014-10-01
[Biochim. Biophys. Acta 1838(10) , 2615-24, (2014)]
2015-01-01
[Drug Dev. Ind. Pharm. 41(1) , 156-62, (2014)]
2014-01-01
[PLoS ONE 9(11) , e112818, (2014)]
2015-03-01
[Tissue Eng. Part A 21(5-6) , 948-59, (2015)]