Biosensors and Bioelectronics 2015-10-15

General approach for electrochemical detection of persistent pharmaceutical micropollutants: Application to acetaminophen.

S Shi, S Reisberg, G Anquetin, V Noël, M C Pham, B Piro

文献索引：Biosens. Bioelectron. 72 , 205-10, (2015)

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摘要

We propose in this work a general and versatile methodology for electrochemical monitoring of persistent pharmaceutical micropollutants. The system presented is based on an electroactive and electropolymerized hapten (mimetic molecule of the pollutant to be detected) and a specific antibody that competitively binds either the hapten or the pollutant. The current delivered by the device depends on this competitive equilibrium and therefore on the pollutant's concentration. The determination of the pharmaceutical product operates within minutes, using square wave voltammetry without labeling or addition of a reactant in solution; the competitive hapten/antibody transduction produces a "signal-on" (a current increase). Applied to acetaminophen, this electrochemical immunosensor presents a very low detection limit of ca. 10 pM, (S/N=3) and a very high selectivity towards structural analogs (aspirin, BPA, and piperazine) even in a mixture.Copyright © 2015 Elsevier B.V. All rights reserved.

相关化合物

  • 叠氮化钠
  • 抗坏血酸
  • 对乙酰氨基苯酚
  • 过硫酸铵
  • 琥珀酸； 丁二酸
  • 2-戊炔酸
  • 4-二甲氨基吡啶
  • 双酚a
  • 叔丁醇
  • 酮康唑侧链

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