Journal of Environmental Biology 2015-07-01

Synthetic and biological studies on thioxoquinazolinone substituted isoxazoles.

K Lakshmi, N Rama Rao, M V Basaveswara Kao

文献索引：J. Environ Biol. 36 , 909-18, (2015)

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摘要

Eighteen novel 5-phenyl-3-(substitutedthioxoquinazolinonyl) isoxazoles (5a-r) were synthesized by cycloaddition of various chalcones with hydroxylaminehydrochloride (NH2OH.HCl). All the newly synthesized compounds were confirmed by their spectral and analytical data. They were evaluated for antimicrobial, antihelminthic, analgesic and anti-inflammatory activities with an objective to evaluate the effect of thioxoquinazolinone substituted isoxazoles. Compounds 5a, 5f, 5g, 5k and 51 showed significant antimicrobial, anthelmintic, analgesic and anti-inflammatory activities. Further, isoxazoles having bromo substituted thioxoquinazolinones exhibited excellent activities than iodo substituted thioxoquinazolinones.

相关化合物

  • 邻氨基苯甲酸
  • 溴化钾
  • 对溴苯胺
  • 亚硫酸丙烯酯

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