Bioorganic & Medicinal Chemistry 2009-08-01

Interaction of drug based binuclear mixed-ligand complexes with DNA.

Mohan N Patel, Mehulsinh R Chhasatia, Deepen S Gandhi

文献索引：Bioorg. Med. Chem. 17 , 5648-55, (2009)

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摘要

Here in we tried to increase an antibacterial activity of ciprofloxacin drug due to formation of mixed-ligand complexes. Synthesized compounds were found to be more potent compare to drugs, ligands and metal salt against selective gram((+ve)) and gram((-ve)) organisms. Interaction of the complexes with nucleic acid (DNA) were investigated using spectroscopic technique, viscosity measurement and gel electrophoresis and it was found that the complexes bind to DNA via intercalative mode.

相关化合物

  • 氧氟沙星
  • 乙二胺
  • 1,8-二氨基萘
  • 氟哌酸
  • 邻苯二胺(OPD)
  • 司帕沙星
  • 恩诺沙星
  • 环丙沙星
  • 左氧氟沙星

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