氧氟沙星结构式
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常用名 | 氧氟沙星 | 英文名 | Ofloxacin |
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| CAS号 | 82419-36-1 | 分子量 | 361.367 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 571.5±50.0 °C at 760 mmHg | |
| 分子式 | C18H20FN3O4 | 熔点 | 270-2750C | |
| MSDS | 中文版 美版 | 闪点 | 299.4±30.1 °C |
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Targeting the gyrase of Plasmodium falciparum with topoisomerase poisons.
Biochem. Pharmacol. 95 , 227-37, (2015) Drug-resistant malaria poses a major public health problem throughout the world and the need for new antimalarial drugs is growing. The apicoplast, a chloroplast-like organelle essential for malaria parasite survival and with no counterpart in humans, offers ... |
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Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli.
Antimicrob. Agents Chemother. 52 , 3052-60, (2008) Active efflux of antimicrobial agents is one of the most important adapted strategies that bacteria use to defend against antimicrobial factors that are present in their environment. The NorM protein of Neisseria gonorrhoeae and the YdhE protein of Escherichi... |
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Evaluation of Antioxidant and Antibacterial Potentials of Nigella sativa L. Suspension Cultures under Elicitation.
Biomed Res. Int. 2015 , 708691, (2015) Nigella sativa L. (family Ranunculaceae) is an annual herb of immense medicinal properties because of its major active components (i.e., thymoquinone (TQ), thymohydroquinone (THQ), and thymol (THY)). Plant tissue culture techniques like elicitation, Agrobacte... |
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Multiresidue determination of fluoroquinolones in poultry muscle and kidney according to the regulation 2002/657/EC. A systematic comparison of two different approaches: Liquid chromatography coupled to high-resolution mass spectrometry or tandem mass spectrometry.
J. Chromatogr. A. 1379 , 83-91, (2015) This work involved the optimization and validation of two methods according to the Commission Decision 2002/657/EC directives for determining fluoroquinolones residues in samples of poultry muscle and kidney: ciprofloxacin, danofloxacin, difloxacin, enrofloxa... |
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Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be tra... |
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Optimization of oleylamine-Fe3O4/MWCNTs nanocomposite modified GC electrode for electrochemical determination of ofloxacin.
J. Nanosci. Nanotechnol. 14(7) , 5059-69, (2014) Iron oxide (Fe3O4) nanoparticles are prepared by nucleation method using oleylamine (OLA) as the capping agent. The OLA capped Fe3O4 nanoparticles (OLA-Fe3O4) are characterized by Fourier Transform Infrared (FT-IR) spectroscopy, X-ray Diffraction (XRD) and Hi... |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Simple analytical strategy for MALDI-TOF-MS and nanoUPLC-MS/MS: quantitating curcumin in food condiments and dietary supplements and screening of acrylamide-induced ROS protein indicators reduced by curcumin.
Food Chem. 174 , 571-6, (2014) Curcumin is the major active ingredient of turmeric and is widely used as a preservative, flavouring and colouring agent. Curcumin is a potent substance with several functions, including antioxidant, antitumor, anti-inflammatory, antimicrobial, antiparasitic,... |
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Age-related pharmacokinetic changes of acetaminophen, antipyrine, diazepam, diphenhydramine, and ofloxacin in male cynomolgus monkeys and beagle dogs.
Xenobiotica 44(10) , 893-901, (2014) 1. The pharmacokinetics of acetaminophen (marker of gastric emptying), antipyrine (marker of hepatic metabolic activity and total body water), diazepam (lipophilic and highly distributed), diphenhydramine (hepatic blood flow-limited and alpha-1 acid glycoprot... |
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Concentration and distribution of antibiotics in water-sediment system of Bosten Lake, Xinjiang.
Environ. Sci. Pollut. Res. Int. 22(3) , 1670-8, (2015) This study investigated the residues of four sulfonamides, four quinolones, and four tetracyclines in surface water as well as surficial sediment samples, of Bosten Lake, in Xinjiang, China. The results showed the presence of 10 out of the 12 selected antibio... |