European Journal of Medicinal Chemistry 2011-05-01

Development of imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors.

Silke Hack, Babette Wörlein, Georg Höfner, Jörg Pabel, Klaus T Wanner

文献索引：Eur. J. Med. Chem. 46 , 1483-98, (2011)

全文：HTML全文

摘要

A new series of potential GABA uptake inhibitors starting from of 1H-imidazol-4-ylacetic acid with the carboxylic acid side chain originating from different positions and varying in length have been synthesized and tested for the inhibitory potency at the four GABA uptake transporters mGAT1-4 stably expressed in HEK cells. Further two bicyclic compounds with a rigidified carboxylic acid side chain were included in this study. The results of the biological tests indicated that most ω-imidazole alkanoic and alkenoic acid derivatives exhibit the highest potencies as GABA uptake inhibitors at mGAT3.Copyright © 2011 Elsevier Masson SAS. All rights reserved.

相关化合物

  • β-丙氨酸
  • 7-氨基庚酸
  • 6-氨基己酸
  • 4-氨基丁酸
  • 甘氨酸
  • 5-氨基戊酸
  • 尿刊酸

相关文献：

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.

2009-02-12

[Nature 457(7231) , 910-4, (2009)]

Automated screening of urine samples for carbohydrates, organic and amino acids after treatment with urease.

[J. Chromatogr. A. 562(1-2) , 125-38, (1991)]

Urinary and plasma organic acids and amino acids in chronic fatigue syndrome.

2005-11-01

[Clin. Chim. Acta 361(1-2) , 150-8, (2005)]

Peptide dimethylation: fragmentation control via distancing the dimethylamino group.

2014-10-01

[J. Am. Soc. Mass Spectrom. 25(10) , 1694-704, (2014)]

Detection of autosomal dominant polycystic kidney disease by NMR spectroscopic fingerprinting of urine.

2011-06-01

[Kidney Int. 79(11) , 1244-53, (2011)]

更多文献...