Journal of Pharmaceutical and Biomedical Analysis 2015-01-01

Identification of a new isomer from a reversible isomerization of ceftriaxone in aqueous solution.

Ye Tian, Li Lu, Yan Chang, Dou-sheng Zhang, Jin Li, Yan-Chun Feng, Chang-Qin Hu

文献索引：J. Pharm. Biomed. Anal. 102 , 326-30, (2015)

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摘要

A reversible isomerization of ceftriaxone in aqueous solution was observed, and the structure of the isomer was determined by mass spectrometry and various 1D and 2D NMR techniques. The mechanism of isomerization was also discussed. Finally, molecular docking simulations were performed and the antimicrobial activities of the isomers were measured. This showed that the biological activity of ceftriaxone was stronger than that of its isomer. The results reported in this article may be important to quality control requirements and to the stability of ceftriaxone products. Copyright © 2014 Elsevier B.V. All rights reserved.

相关化合物

  • 乙腈
  • 甲醇
  • 头孢曲松钠

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