Flavonoids from the aerial parts of Houttuynia cordata attenuate lung inflammation in mice.
Ju Hee Lee, Jongmin Ahn, Jin Woong Kim, Sang Gook Lee, Hyun Pyo Kim
文献索引:Arch. Pharm. Res. 38 , 1304-11, (2015)
全文:HTML全文
摘要
The aerial parts of Houttuynia cordata used for treating inflammation-related disorders contain flavonoids as major constituents. Since certain flavonoids possess anti-inflammatory activity, especially in the lung, the pharmacological activities of H. cordata and the flavonoid constituents were evaluated using in vitro and in vivo models of lung inflammation. The 70 % ethanol extract of the aerial parts of H. cordata inhibited the production of inflammatory biomarkers IL-6 and NO in lung epithelial cells (A549) and alveolar macrophages (MH-S), respectively. And the same plant material, administered orally (100 and 400 mg/kg), significantly inhibited lung inflammatory response in a mouse model of lipopolysaccharide (LPS)-induced acute lung injury. From the extract, major flavonoids including afzelin, hyperoside and quercitrin were successfully isolated and they also attenuated LPS-induced lung inflammation in mice by oral administration. In particular, quercitrin showed most potent activity at 100 mg/kg. These results demonstrate for the first time that H. cordata and three flavonoid constituents have a therapeutic potential for treating lung inflammatory disorders.
相关化合物
相关文献:
2015-04-13
[Biomacromolecules 16(4) , 1382-9, (2015)]
2015-04-15
[Biochem. J. 467(2) , 345-52, (2015)]
2015-05-01
[Biochem. J. 467(3) , 425-38, (2015)]
2015-04-01
[J. Virol. 89(8) , 4421-33, (2015)]
2015-01-01
[Nat. Commun. 6 , 5853, (2015)]