Amentoflavone protects hippocampal neurons: anti-inflammatory, antioxidative, and antiapoptotic effects.
Zhen Zhang, Tao Sun, Jian-Guo Niu, Zhen-Quan He, Yang Liu, Feng Wang
文献索引:Neural Regen. Res. 10 , 1125-33, (2015)
全文:HTML全文
摘要
Amentoflavone is a natural biflavone compound with many biological properties, including anti-inflammatory, antioxidative, and neuroprotective effects. We presumed that amentoflavone exerts a neuroprotective effect in epilepsy models. Prior to model establishment, mice were intragastrically administered 25 mg/kg amentoflavone for 3 consecutive days. Amentoflavone effectively prevented pilocarpine-induced epilepsy in a mouse kindling model, suppressed nuclear factor-κB activation and expression, inhibited excessive discharge of hippocampal neurons resulting in a reduction in epileptic seizures, shortened attack time, and diminished loss and apoptosis of hippocampal neurons. Results suggested that amentoflavone protected hippocampal neurons in epilepsy mice via anti-inflammation, antioxidation, and antiapoptosis, and then effectively prevented the occurrence of seizures.
相关化合物
相关文献:
2015-04-13
[Biomacromolecules 16(4) , 1382-9, (2015)]
2015-04-15
[Biochem. J. 467(2) , 345-52, (2015)]
2015-05-01
[Biochem. J. 467(3) , 425-38, (2015)]
2015-04-01
[J. Virol. 89(8) , 4421-33, (2015)]
2015-01-01
[Nat. Commun. 6 , 5853, (2015)]