Bioanalysis 2015-01-01

Simultaneous determination of trimethoprim and sulfamethoxazole in dried plasma and urine spots.

Daniel Gonzalez, Chiara Melloni, Brenda B Poindexter, Ram Yogev, Andrew M Atz, Janice E Sullivan, Susan R Mendley, Paula Delmore, Amy Delinsky, Kanecia Zimmerman, Andrew Lewandowski, Barrie Harper, Kenneth C Lewis, Daniel K Benjamin, Michael Cohen-Wolkowiez

文献索引：Bioanalysis 7 , 1137-49, (2015)

全文：HTML全文

摘要

Trimethoprim-sulfamethoxazole (TMP-SMX) is an antimicrobial drug combination commonly prescribed in children and adults. The study objectives were to validate and apply an HPLC-MS/MS method to quantify TMP-SMX in dried plasma spots (DPS) and dried urine spots (DUS), and perform a comparability analysis with liquid matrices.For TMP the validated range was 100-50,000 ng/ml for DPS and 500-250,000 ng/ml for DUS; for SMX, the validated range was 1000-500,000 ng/ml for both DPS and DUS. Good agreement was noted between DPS/DUS and liquid plasma and urine samples for TMP, while only modest agreement was observed for SMX in both matrices.A precise, accurate and reproducible method was developed to quantify TMP-SMX in DPS and DUS samples.

相关化合物

  • 甲醇
  • 反式-4,4ˊ-二苯基芪

相关文献：

BBS4 directly affects proliferation and differentiation of adipocytes.

2014-09-01

[Cell. Mol. Life Sci. 71(17) , 3381-92, (2014)]

Urinary metabolic fingerprinting of mice with diet-induced metabolic derangements by parallel dual secondary column-dual detection two-dimensional comprehensive gas chromatography.

2014-09-26

[J. Chromatogr. A. 1361 , 265-76, (2014)]

Biomolecular imaging with a C60-SIMS/MALDI dual ion source hybrid mass spectrometer: instrumentation, matrix enhancement, and single cell analysis.

2014-11-01

[J. Am. Soc. Mass Spectrom. 25(11) , 1897-907, (2014)]

Synergistic activity of tenofovir and nevirapine combinations released from polycaprolactone matrices for potential enhanced prevention of HIV infection through the vaginal route.

2014-10-01

[Eur. J. Pharm. Biopharm. 88(2) , 406-14, (2014)]

Antinematode activity of Violacein and the role of the insulin/IGF-1 pathway in controlling violacein sensitivity in Caenorhabditis elegans.

2014-01-01

[PLoS ONE 9(10) , e109201, (2014)]

更多文献...