Novel and efficient synthesis and antifungal evaluation of 2,3-functionalized cholestane and androstane derivatives

Branko S. Jursic, Sunil Kumar Upadhyay, Clinton C. Creech, Donna M. Neumann, Branko S. Jursic, Sunil Kumar Upadhyay, Clinton C. Creech, Donna M. Neumann

文献索引：Bioorg. Med. Chem. Lett. 20 , 7372-5, (2010)

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摘要

Synthetic modifications of cholesterol and other traditional steroid molecules have become a promising area for the exploration and development of novel antifungal agents, especially with respect to the development of fatty-acid esters of steroids. In addition, 2,3-functionalized steroids are also compounds with potentially interesting biological properties and proper functionalization of 2,3-steroids can lead to the development of efficient syntheses of building blocks for novel fatty-acid esters of steroids. In this Letter, we outline a novel and efficient approach to the synthesis of 2,3-functionalized cholestane and androstane derivatives and present their promising preliminary antifungal activities against a number of fungal species.Copyright © 2010 Elsevier Ltd. All rights reserved.