5α-Androstan-3β-ol
5α-Androstan-3β-ol结构式
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常用名 | 5α-Androstan-3β-ol | 英文名 | 5a-androstan-3b-ol |
|---|---|---|---|---|
| CAS号 | 1224-92-6 | 分子量 | 276.457 | |
| 密度 | 1.0±0.1 g/cm3 | 沸点 | 375.9±10.0 °C at 760 mmHg | |
| 分子式 | C19H32O | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 158.4±11.5 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.
J. Med. Chem. 48 , 5666-74, (2005) We investigated the influence of induced fit of the androgen receptor binding pocket on free energies of ligand binding. On the basis of a novel alignment procedure using flexible docking, molecular dynamics simulations, and linear-interaction energy analysis... |
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The pheromone androstenol (5 alpha-androst-16-en-3 alpha-ol) is a neurosteroid positive modulator of GABAA receptors.
J. Pharmacol. Exp. Ther. 317(2) , 694-703, (2006) Androstenol is a steroidal compound belonging to the group of odorous 16-androstenes, first isolated from boar testes and also found in humans. Androstenol has pheromone-like properties in both animals and humans, but the molecular targets of its pheromonal a... |
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Synthesis of novel D-ring fused 7'-aryl-androstano[17,16-d][1,2,4] triazolo[1,5-a]pyrimidines.
Steroids 77(5) , 367-74, (2012) The preparation of novel steroidal heterocycles containing the 7-aryl-substituted 1,2,4-triazolo[1,5-a]pyrimidine moiety fused to the 16,17-positions of the steroid nucleus is described. The Aldol reaction of 4-aza-androst-3,17-dione (1a) and dehydroepiandros... |
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Sex difference in the proliferative response of mouse hepatocytes to treatment with the CAR ligand, TCPOBOP.
Carcinogenesis 24(6) , 1059-65, (2003) The nuclear receptor Constitutive Androstane Receptor (CAR) binds DNA as a heterodimer with the retinoic-X receptor and activates gene transcription. Previously, in vitro studies have shown that the testosterone metabolites, androstenol and androstenol, inhib... |
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Hydrogen bonding between the 17beta-substituent of a neurosteroid and the GABA(A) receptor is not obligatory for channel potentiation.
Br. J. Pharmacol. 158(5) , 1322-9, (2009) Potentiating neurosteroids are some of the most efficacious modulators of the mammalian GABA(A) receptor. One of the crucial interactions may be between the C20 ketone group (D-ring substituent at C17) of the neurosteroid, and the N407 and Y410 residues in th... |
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Effects of 1,8-cineole on the dynamics of lipids and proteins of stratum corneum.
Int. J. Pharm. 345(1-2) , 81-7, (2007) The interaction of a potent percutaneous penetration enhancer, 1,8-cineole, with the stratum corneum (SC) and DPPC membranes was investigated by electron paramagnetic resonance spectroscopy (EPR) of spin-labeled analogs of stearic acid (5-DSA) and androstanol... |
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GC-MS studies of 16-androstenes and other C19 steroids in human semen.
J. Steroid Biochem. Mol. Biol. 43(6) , 549-56, (1992) Human semen was examined for the presence of 16-androstenols, 16-androstenones and androgens. Extracts were analysed by gas chromatography-mass spectrometry after derivatization of steroids under study. In a qualitative study, 5 alpha-androst-16-en-3 alpha- a... |
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Role of nuclear receptor CAR in carbon tetrachloride-induced hepatotoxicity.
World J. Gastroenterol. 11(38) , 5966-72, (2005) To investigate the precise roles of CAR in CCl(4)-induced acute hepatotoxicity.To prepare an acute liver injury model, CCl(4) was intraperitoneally injected in CAR+/+ and CAR-/- mice.Elevation of serum alanine aminotransferase and extension of centrilobular n... |
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Novel and efficient synthesis and antifungal evaluation of 2,3-functionalized cholestane and androstane derivatives
Bioorg. Med. Chem. Lett. 20 , 7372-5, (2010) Synthetic modifications of cholesterol and other traditional steroid molecules have become a promising area for the exploration and development of novel antifungal agents, especially with respect to the development of fatty-acid esters of steroids. In additio... |
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17beta-Nitro-5alpha-androstan-3alpha-ol and its 3beta-methyl derivative: neurosteroid analogs with potent anticonvulsant and anxiolytic activities.
Eur. J. Pharmacol. 617(1-3) , 68-73, (2009) Many 17-substituted androstan-3alpha-ol analogs act as positive allosteric modulators of GABA(A) receptors and exert anticonvulsant and anxiolytic-like activity actions in animal models. The endogenous neurosteroid allopregnanolone (17beta-acetyl; 1) is among... |