Langmuir 2007-06-19

Effect of agents modifying the membrane dipole potential on properties of syringomycin E channels.

Olga S Ostroumova, Yuri A Kaulin, Philip A Gurnev, Ludmila V Schagina

文献索引：Langmuir 23(13) , 6889-92, (2007)

全文：HTML全文

摘要

We evaluated the effect of agents modifying the membrane dipole potential: phloretin, 6-ketocholestanol and RH 421 on the properties of single channels formed by lipodepsipeptide syringomycin E (SRE) in planar lipid bilayers. SRE forms two conductive states in lipid bilayers: "small" and "large." Large SRE channels are clusters of several small ones, demonstrating synchronous openings and closures. The increase in the membrane dipole potential led to (i) an increase in SRE channel conductance, (ii) an increase in the channel's lifetime, and (iii) a decrease in a number of synchronously operating small channels in the clusters. Overall, the results support the model of the small SRE channel synchronization in the cluster as voltage-dependent orientation of the lipid dipoles associated with the channel pores.

相关化合物

  • N-(4-磺酸丁基)-4-(...
  • syringomycin E
  • 3Β-羟基-5Α-(1,5-...

相关文献：

Membrane dipole modifiers modulate single-length nystatin channels via reducing elastic stress in the vicinity of the lipid mouth of a pore.

2015-01-01

[Biochim. Biophys. Acta 1848(1 Pt A) , 192-9, (2015)]

[The effects of RH 421 on the activity of amphotericin B in cell and model membranes].

2013-01-01

[Tsitologiia 55(2) , 136-9, (2013)]

Probing amphotericin B single channel activity by membrane dipole modifiers.

2012-01-01

[PLoS ONE 7(1) , e30261, (2012)]

Effect of gramicidin A on the dipole potential of phospholipid membranes.

1999-07-01

[Biophys. J. 77(1) , 299-305, (1999)]

Electrogenic plasma membrane H+-ATPase activity using voltage sensitive dyes.

2010-10-01

[J. Bioenerg. Biomembr. 42(5) , 387-93, (2010)]

更多文献...