N-(4-磺酸丁基)-4-(4-(4-(二戊基氨基)苯基)丁二烯基)吡啶内盐结构式
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常用名 | N-(4-磺酸丁基)-4-(4-(4-(二戊基氨基)苯基)丁二烯基)吡啶内盐 | 英文名 | RH 421 |
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| CAS号 | 107610-19-5 | 分子量 | 498.72000 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C29H42N2O3S | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Membrane dipole modifiers modulate single-length nystatin channels via reducing elastic stress in the vicinity of the lipid mouth of a pore.
Biochim. Biophys. Acta 1848(1 Pt A) , 192-9, (2015) The polyene antifungal antibiotic nystatin confers its biological activity by forming pores in the membranes of target cells. Exposure of only one side of the membrane to nystatin is more relevant than two-side exposure because in vivo antibiotic molecules in... |
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[The effects of RH 421 on the activity of amphotericin B in cell and model membranes].
Tsitologiia 55(2) , 136-9, (2013) The combined action of polyene macrolide antibiotic amphotericin B and styryl dye RH 421 in model lipid membranes and in yeast Saccharomyces cerevisiae has been studied. RH 421 insertion inti the ergosterol-containing lipid bilayers led to the increase of the... |
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Probing amphotericin B single channel activity by membrane dipole modifiers.
PLoS ONE 7(1) , e30261, (2012) The effects of dipole modifiers and their structural analogs on the single channel activity of amphotericin B in sterol-containing planar phosphocholine membranes are studied. It is shown that the addition of phloretin in solutions bathing membranes containin... |
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Effect of gramicidin A on the dipole potential of phospholipid membranes.
Biophys. J. 77(1) , 299-305, (1999) The effect of channel-forming peptide gramicidin A on the dipole potential of phospholipid monolayers and bilayers has been studied. Surface pressure and surface potential isotherms of monolayers have been measured with a Langmuir trough equipped with a Wilhe... |
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Electrogenic plasma membrane H+-ATPase activity using voltage sensitive dyes.
J. Bioenerg. Biomembr. 42(5) , 387-93, (2010) Fast responding voltage sensitive dyes, RH421 and di-4-ASPBS, were used to study the electrogenic properties of plant plasma membrane proton pumps on sealed plasma membrane vesicles extracted by two-phase partitioning from Beta vulgaris and Avena sativa cv Sw... |
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Effect of agents modifying the membrane dipole potential on properties of syringomycin E channels.
Langmuir 23(13) , 6889-92, (2007) We evaluated the effect of agents modifying the membrane dipole potential: phloretin, 6-ketocholestanol and RH 421 on the properties of single channels formed by lipodepsipeptide syringomycin E (SRE) in planar lipid bilayers. SRE forms two conductive states i... |
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Palytoxin-induced effects on partial reactions of the Na,K-ATPase.
J. Gen. Physiol. 128(1) , 103-18, (2006) The interaction of palytoxin with the Na,K-ATPase was studied by the electrochromic styryl dye RH421, which monitors the amount of ions in the membrane domain of the pump. The toxin affected the pump function in the state P-E2, independently of the type of ph... |
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The RH 421 styryl dye induced, pore model-dependent modulation of antimicrobial peptides activity in reconstituted planar membranes.
Biochim. Biophys. Acta 1790(8) , 809-16, (2009) Antimicrobial agents, with different pore-formation mechanisms, may be differently influenced by alteration of the dipolar electric field of a lipid membrane.By using electrophysiological measurements on reconstituted lipid membranes, we used alamethicin, mel... |
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Ion selectivity of the cytoplasmic binding sites of the Na,K-ATPase: I. Sodium binding is associated with a conformational rearrangement.
J. Membr. Biol. 168(3) , 221-8, (1999) To investigate Na+ binding to the ion-binding sites presented on the cytoplasmic side of the Na,K-ATPase, equilibrium Na+-titration experiments were performed using two fluorescent dyes, RH421 and FITC, to detect protein-specific actions. Fluorescence changes... |
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Eosin, energy transfer, and RH421 report the same conformational change in sodium pump as fluorescein.
Ann. N. Y. Acad. Sci. 834 , 442-4, (1997)
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