Journal of chromatography. B, Biomedical applications 1994-11-04

Radical-derived oxidation products of 5-aminosalicylic acid and N-acetyl-5-aminosalicylic acid.

C Fischer, U Klotz

文献索引：J. Chromatogr. B, Biomed. Appl. 661(1) , 57-68, (1994)

全文：HTML全文

摘要

5-Aminosalicylic acid is an agent effective in the treatment of chronic inflammatory bowel diseases. Its ability to scavenge radicals is considered to be a major factor responsible for its therapeutic efficacy. In this study oxidation products of aminosalicylates with hydroxyl radicals were produced. The compounds that could be discovered by gas chromatographic-mass spectrometric analysis originate from a 1,4-benzoquinone monoimine intermediate which subsequently undergoes multiple reactions such as hydrolysis, reductive 1,4-Michael addition, reoxidation and decarboxylation. Some of these products could represent metabolites formed under in vivo conditions and thus provide a tool for screening biological material from subjects under different clinical conditions.

相关化合物

  • 5-乙酰氨基水杨酸

相关文献：

Simultaneous determination of 5-aminosalicylic acid, acetyl-5-aminosalicylic acid and 2,5-dihydroxybenzoic acid in endoscopic intestinal biopsy samples in humans by high-performance liquid chromatography with electrochemical detection.

1995-12-01

[J. Pharm. Biomed. Anal. 14(1-2) , 175-80, (1995)]

Safety, efficacy, and pharmacokinetics of balsalazide in pediatric patients with mild-to-moderate active ulcerative colitis: results of a randomized, double-blind study.

2009-11-01

[J. Pediatr. Gastroenterol. Nutr. 49(5) , 571-9, (2009)]

Superoxide inhibition following different stimuli of respiratory burst and metabolism of aminosalicylates in neutrophils.

1994-01-01

[Dig. Dis. Sci. 39(1) , 145-51, (1994)]

Pharmacokinetic studies of benzalazine.

1994-12-01

[Arzneimittelforschung 44(12) , 1381-3, (1994)]

Inhibitory effect of flavonoids on the efflux of N-acetyl 5-aminosalicylic acid intracellularly formed in Caco-2 cells.

2009-01-01

[J. Biomed. Biotechnol. 2009 , 467489, (2009)]

更多文献...