5-乙酰氨基水杨酸
5-乙酰氨基水杨酸结构式
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常用名 | 5-乙酰氨基水杨酸 | 英文名 | N-Acetyl Mesalazine |
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| CAS号 | 51-59-2 | 分子量 | 195.17 | |
| 密度 | 1.462 g/cm3 | 沸点 | 480.2ºC at 760 mmHg | |
| 分子式 | C9H9NO4 | 熔点 | 228-230ºC | |
| MSDS | 中文版 美版 | 闪点 | 244.2ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Simultaneous determination of 5-aminosalicylic acid, acetyl-5-aminosalicylic acid and 2,5-dihydroxybenzoic acid in endoscopic intestinal biopsy samples in humans by high-performance liquid chromatography with electrochemical detection.
J. Pharm. Biomed. Anal. 14(1-2) , 175-80, (1995) A high-performance liquid chromatographic method for the simultaneous determination of 5-aminosalicylic acid (5-ASA), acetyl-5-aminosalicylic acid (Ac-5-ASA) and 2,5-dihydroxybenzoic acid (5-HSA) in human endoscopic intestinal biopsy with electrochemical dete... |
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Safety, efficacy, and pharmacokinetics of balsalazide in pediatric patients with mild-to-moderate active ulcerative colitis: results of a randomized, double-blind study.
J. Pediatr. Gastroenterol. Nutr. 49(5) , 571-9, (2009) : A multicenter, double-blind study was conducted to evaluate the safety, efficacy, and pharmacokinetics of balsalazide in pediatric patients with mild-to-moderate ulcerative colitis (UC).: Sixty-eight patients, 5 to 17 years of age, with mild-to-moderate act... |
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Radical-derived oxidation products of 5-aminosalicylic acid and N-acetyl-5-aminosalicylic acid.
J. Chromatogr. B, Biomed. Appl. 661(1) , 57-68, (1994) 5-Aminosalicylic acid is an agent effective in the treatment of chronic inflammatory bowel diseases. Its ability to scavenge radicals is considered to be a major factor responsible for its therapeutic efficacy. In this study oxidation products of aminosalicyl... |
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Superoxide inhibition following different stimuli of respiratory burst and metabolism of aminosalicylates in neutrophils.
Dig. Dis. Sci. 39(1) , 145-51, (1994) Reactive oxygen species such as superoxide radicals have been proposed to play an important role in the pathogenesis of inflammatory bowel disease. Some of the antiinflammatory actions of aminosalicylates have been ascribed to their capability to scavenge sup... |
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Pharmacokinetic studies of benzalazine.
Arzneimittelforschung 44(12) , 1381-3, (1994) The pharmacokinetic properties of benzalazine ((2-hydroxy-5-[(4-carboxyphenyl)azo]benzoic acid, CAS 64896-26-0), a new agent for the treatment of ulcerative colitis and Crohn's disease of the large intestine, were investigated. From jejunal loops of rats in s... |
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Inhibitory effect of flavonoids on the efflux of N-acetyl 5-aminosalicylic acid intracellularly formed in Caco-2 cells.
J. Biomed. Biotechnol. 2009 , 467489, (2009) N-acetyl 5-aminosalicylic acid (5-AcASA) that was intracellularly formed from 5-aminosalicylic acid (5-ASA) at 200 microM was discharged 5.3, 7.1, and 8.1-fold higher into the apical site than into the basolateral site during 1, 2, and 4-hour incubations, res... |
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Effect of quercetin on the transport of N-acetyl 5-aminosalicylic acid.
J. Pharm. Pharmacol. 65(7) , 1037-43, (2013) The aim of this study was to investigate the transporter-mediated transport of N-acetyl 5-aminosalicylic acid (Ac-5-ASA) and the effect of quercetin on Ac-5-ASA transport.Caco-2 cell monolayers grown in Transwells were used to study the transport of Ac-5-ASA ... |
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Topical acetyl salicylate and dipyrone attenuate neurogenic protein extravasation in rat skin in vivo.
Neurosci. Lett. 290(1) , 57-60, (2000) The effect of topically applied acetyl salicylic acid (ASA) and dipyrone on capsaicin-evoked protein extravasation was investigated by dermal microdialysis in rat. After a baseline of 75 min, capsaicin (1%) was applied epicutaneously under occlusion for 75 mi... |
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Intrarectal administration of 5-aminosalicylic acid to rabbits and dogs.
Hum. Exp. Toxicol. 21(3) , 159-63, (2002) Intrarectal administration of 5-aminosalicylic acid (5-ASA) to rabbits and dogs was performed to obtain safety data. Groups of rabbits and dogs received twice daily intrarectal doses of 250, 500 or 1000 mg 5-ASA for 14 consecutive days. Treatment had no adver... |
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Systemic absorption of 5-aminosalicylic acid in patients with inactive ulcerative colitis treated with olsalazine and mesalazine.
Eur. J. Gastroenterol. Hepatol. 9(7) , 729-30, (1997)
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