Journal of Medicinal Chemistry 1992-10-30

Adenosine deaminase inhibitors. Synthesis and biological evaluation of C1' and nor-C1' derivatives of (+)-erythro-9-(2(S)-hydroxy-3(R)-nonyl)adenine.

G C Harriman, A F Poirot, E Abushanab, R M Midgett, J D Stoeckler

文献索引：J. Med. Chem. 35(22) , 4180-4, (1992)

全文：HTML全文

摘要

The synthesis of various chiral derivatives of (+)-erythro-9-(2-hydroxy-3-nonyl)adenine, (+)-EHNA, from (2S,3R)-3-amino-1,2-O-isopropylidene-1,2-nonanediol by condensation with 5-amino-4,6-dichloropyrimidine is described. The compounds synthesized were C1'- and nor-C1'-(+)-EHNA derivatives. When tested with calf spleen ADA, C1'-OH- and nor-C1'-(+)-EHNA had comparable inhibitory activity that was 1 order of magnitude lower than that of (+)-EHNA. Potency was reduced further in nor-C1' derivatives.

相关化合物

  • 4,6-二氯-5-氨基嘧...

相关文献：

6-(Alkylamino)-9-benzyl-9H-purines. A new class of anticonvulsant agents.

1988-03-01

[J. Med. Chem. 31(3) , 606-12, (1988)]

An efficient and regiospecific strategy to N7-substituted purines and its application to a library of trisubstituted purines.

2006-01-01

[J. Comb. Chem. 8(3) , 410-6, (2006)]

Synthesis of oxepane ring containing monocyclic, conformationally restricted bicyclic and spirocyclic nucleosides from D-glucose: a cycloaddition approach.

2007-09-14

[J. Org. Chem. 72(19) , 7427-30, (2007)]

Sequential ring-closing metathesis and nitrone cycloaddition on glucose-derived substrates: a divergent approach to analogues of spiroannulated carbanucleosides and conformationally locked nucleosides.

2006-08-04

[J. Org. Chem. 71(16) , 5980-92, (2006)]

[Tetrahedron Lett. 48 , 1489, (2007)]

更多文献...