Highly selective asymmetric acetate aldol reactions of an N-acetyl thiazolidinethione reagent.
Yingchao Zhang, Andrew J Phillips, Tarek Sammakia
文献索引:Org. Lett. 6 , 23-25, (2004)
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摘要
[reaction: see text] A highly diastereoselective acetate aldol reaction that uses a tert-leucine-derived thiazolidinethione auxiliary and dichlorophenylborane has been developed. The reaction proceeds in excellent yields and with high diastereoselectivities (drs range from 9.5:1 to >100:1).
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