Journal of medicinal and pharmaceutical chemistry 2008-07-10

Efficient synthesis and neuroprotective effect of substituted 1,3-diphenyl-2-propen-1-ones.

Jae-Chul Jung, Soyong Jang, Yongnam Lee, Dongguk Min, Eunyoung Lim, Heyin Jung, Miyeon Oh, Seikwan Oh, Mankil Jung

文献索引：J. Med. Chem. 51 , 4054-8, (2008)

全文：HTML全文

摘要

An efficient synthesis involving a key aldol reaction and biological properties of 1,3-diphenyl-2-propen-1-ones 8- 20 is described. The in vitro activity for 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging of 10 and 11 was 2 times higher than that for resveratrol. Compounds 9 and 11 were the strongest in suppression of in vitro nitric oxide (NO) generation and antiexcitotoxicity. Molecular modeling proposes an electron-donating group at the para position of acetophenones that leads to a dramatic increase in the suppression of NO production.

相关化合物

  • 白藜芦醇
  • 反-戊烯二酸
  • 戊烯二酸

相关文献：

Mitochondrial impairment triggers cytosolic oxidative stress and cell death following proteasome inhibition.

2014-01-01

[Sci. Rep. 4 , 5896, (2014)]

Phytoestrogens induce differential effects on both normal and malignant human breast cells in vitro.

2014-12-01

[Climacteric 17(6) , 682-91, (2014)]

Assessment of the potential of polyphenols as a CYP17 inhibitor free of adverse corticosteroid elevation.

2014-08-01

[Biochem. Pharmacol. 90(3) , 288-96, (2014)]

Green synthesis of bacterial gold nanoparticles conjugated to resveratrol as delivery vehicles.

2014-11-01

[Colloids Surf. B Biointerfaces 123 , 311-7, (2014)]

Mechanism of Dose-Dependent Regulation of UBE1L by Polyphenols in Human Bronchial Epithelial Cells.

2015-08-01

[J. Cell. Biochem. 116 , 1553-62, (2015)]

更多文献...