Journal of Physical Chemistry A: Molecules, Spectroscopy, Kinetics, Environment and General Theory 2012-08-23

Photoelectron spectra of some antibiotic building blocks: 2-azetidinone and thiazolidine-carboxylic acid.

Marawan Ahmed, Aravindhan Ganesan, Feng Wang, Vitaliy Feyer, Oksana Plekan, Kevin C Prince

文献索引：J. Phys. Chem. A 116(33) , 8653-60, (2012)

全文：HTML全文

摘要

X-ray photoelectron spectra of the core and valence levels of the fundamental building blocks of β-lactam antibiotics have been investigated and compared with theoretical calculations. The spectra of the compounds 2-azetidinone and the 2- and 4-isomers of thiazolidine-carboxylic acid are interpreted in the light of theoretical calculations. The spectra of the two isomers of thiazolidine-carboxylic acid are rather similar, as expected, but show clear effects due to isomerization. Both isomers are analogues of proline, which is well-known to populate several low energy conformers in the gas phase. We have investigated the low energy conformers of thiazolidine-4-carboxylic acid theoretically in more detail and find some spectroscopic evidence that multiple conformers may be present. The measured valence levels are assigned for all three compounds, and the character of the frontier orbitals is identified and analyzed.

相关化合物

  • L-硫代脯氨酸
  • 2-氮杂环丁酮

相关文献：

Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1).

2011-11-01

[Bioorg. Med. Chem. 19 , 6409-18, (2011)]

Design, synthesis and biological evaluation of 2-(substituted phenyl)thiazolidine-4-carboxylic acid derivatives as novel tyrosinase inhibitors.

2012-02-01

[Biochimie 94(2) , 533-40, (2012)]

Successful computer guided planned synthesis of (4R)-thiazolidine carboxylic acid and its 2-substituted analogues as urease inhibitors.

2006-05-01

[Mol. Divers. 10(2) , 223-31, (2006)]

Synthesis, calpain inhibitory activity, and cytotoxicity of P2-substituted proline and thiaproline peptidyl aldehydes and peptidyl alpha-ketoamides.

2006-08-24

[J. Med. Chem. 49(17) , 5282-90, (2006)]

Lithium thiazolidine-4-carboxylate: synthesis, spectroscopic characterization and preliminary in vitro cytotoxic studies in human HeLa cells.

2008-12-01

[Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 71(3) , 929-31, (2008)]

更多文献...