L-硫代脯氨酸结构式
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常用名 | L-硫代脯氨酸 | 英文名 | L-Thioproline |
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| CAS号 | 34592-47-7 | 分子量 | 133.169 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 350.3±37.0 °C at 760 mmHg | |
| 分子式 | C4H7NO2S | 熔点 | 190-200 °C (dec.)(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 165.7±26.5 °C | |
| 符号 |
GHS06 |
信号词 | Danger |
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Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1).
Bioorg. Med. Chem. 19 , 6409-18, (2011) The proton-coupled amino acid transporter hPAT1 has recently gained much interest due to its ability to transport small drugs thereby allowing their oral administration. A three-dimensional quantitative structure-activity relationship (3D QSAR) study has been... |
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Design, synthesis and biological evaluation of 2-(substituted phenyl)thiazolidine-4-carboxylic acid derivatives as novel tyrosinase inhibitors.
Biochimie 94(2) , 533-40, (2012) Herein we describe the design, synthesis and biological activities of 2-(substituted phenyl)thiazolidine-4-carboxylic acid derivatives as novel tyrosinase inhibitors. The target compounds 2a-2j were designed and synthesized from the structural characteristics... |
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Successful computer guided planned synthesis of (4R)-thiazolidine carboxylic acid and its 2-substituted analogues as urease inhibitors.
Mol. Divers. 10(2) , 223-31, (2006) By using internal combinatorial library we were able to identify (4R)-thiazolidines carboxylic acid and its 2-substituted analogs as active inhibitors of urease. Molecular modeling and virtual screening were utilized to find out potential compounds. Computati... |
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Synthesis, calpain inhibitory activity, and cytotoxicity of P2-substituted proline and thiaproline peptidyl aldehydes and peptidyl alpha-ketoamides.
J. Med. Chem. 49(17) , 5282-90, (2006) Calpain is a cytosolic cysteine endopeptidase that has been implicated in a number of disorders including cancer. We have synthesized and studied the mu-calpain inhibitory activity and cytotoxicity of peptidyl aldehydes and peptidyl alpha-ketoamides with N-su... |
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Lithium thiazolidine-4-carboxylate: synthesis, spectroscopic characterization and preliminary in vitro cytotoxic studies in human HeLa cells.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 71(3) , 929-31, (2008) A new water-soluble lithium salt of thiazolidine-4-carboxylic acid was synthesized and characterized by chemical and spectroscopic techniques. Elemental and mass spectrometric (ESI-MS) analyses of the solid compound fit to the composition LiC(4)H(6)NSO(2). (1... |
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Thioproline prevents carcinogenesis in the remnant stomach induced by duodenal reflux.
Cancer Lett. 237(2) , 256-62, (2006) An excessive duodenal reflux induced by surgery has been widely accepted to cause gastric carcinogenesis in the remnant stomach. As one of causative factors for malignancy, N-nitroso compounds produced by enteric bacteria have been postulated. However, there ... |
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Conformational studies of proline-, thiaproline- and dimethylsilaproline-containing diketopiperazines.
J. Pept. Sci. 12(10) , 621-5, (2006) As proline plays an important role in biologically active peptides, many analogues of this residue have been developed to modulate the proportion of cis and trans conformers. A correlation between the pyrrolidine ring shape and structural properties of prolin... |
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Effect of radioprotective agents in sporulation medium on Bacillus subtilis spore resistance to hydrogen peroxide, wet heat and germicidal and environmentally relevant UV radiation.
J. Appl. Microbiol. 110(6) , 1485-94, (2011) To determine the effects of cysteine, cystine, proline and thioproline as sporulation medium supplements on Bacillus subtilis spore resistance to hydrogen peroxide (H(2)O(2)), wet heat, and germicidal 254 nm and simulated environmental UV radiation.Bacillus s... |
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Determination of thiazolidine-4-carboxylates in urine by chloroformate derivatization and gas chromatography-electron impact mass spectrometry.
J. Mass Spectrom. 42(9) , 1225-32, (2007) The derivatization method of thiazolidine-4-carboxylic acid (TZCA) and methyl-thiazolidine-4-carboxylic acid (Me-TZCA) in urine with alcohol/chloroformate was achieved. TZCA and Me-TZCA were derivatized in one step in urine with ethyl chloroformate in 1 min a... |
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Crystal structures of (2R,4R)-2-(polyhydroxyalkyl)-1,3-thiazolidine-4-carboxylic acids: condensation products of l-cysteine with d-hexoses.
Carbohydr. Res. 346(1) , 127-32, (2011) We report herein the first crystal structures of (4-carboxy-1,3-thiazolidin-2-yl)pentitols [2-(polyhydroxyalkyl)thiazolidine-4-carboxylic acids], condensation products of l-cysteine with d-galactose and d-mannose: 2-(d-galacto-pentahydroxypentyl)thiazolidine-... |