Journal of Veterinary Pharmacology and Therapeutics 2008-12-01

Pharmacokinetics of erythromycin after the administration of intravenous and various oral dosage forms to dogs.

G A Albarellos, V E Kreil, L A Ambros, S Waxman, L Montoya, L Tarragona, P C Quaine, R E Hallu, M Rebuelto

文献索引:J. Vet. Pharmacol. Ther. 31(6) , 496-500, (2008)

全文:HTML全文

摘要

The purpose of this study was to describe and compare the pharmacokinetic properties of different formulations of erythromycin in dogs. Erythromycin was administered as lactobionate (10 mg/kg, IV), estolate tablets (25 mg/kg p.o.) and ethylsuccinate tablets or suspension (20 mg/kg p.o.). After intravenous (i.v.) administration, the principal pharmacokinetic parameters were (mean +/- SD): AUC((0-infinity)) 4.20 +/- 1.66 microg x h/mL; C(max) 6.64 +/- 1.38 microg/mL; V(z) 4.80 +/- 0.91 L/kg; Cl(t) 2.64 +/- 0.84 L/h.kg; t((1/2)lambda) 1.35 +/- 0.40 h and MRT 1.50 +/- 0.47 h. After the administration of estolate tablets and ethylsuccinate suspension, the principal pharmacokinetic parameters were (mean +/- SD): C(max), 0.30 +/- 0.17 and 0.17 +/- 0.09 microg/mL; t(max), 1.75 +/- 0.76 and 0.69 +/- 0.30 h; t((1/2)lambda), 2.92 +/- 0.79 and 1.53 +/- 1.28 h and MRT, 5.10 +/- 1.12 and 2.56 +/- 1.77 h, respectively. The administration of erythromycin ethylsuccinate tablets did not produce measurable serum concentrations. Only the i.v. administration rendered serum concentrations above MIC(90) = 0.5 microg/mL for 2 h. However, these results should be cautiously interpreted as tissue erythromycin concentrations have not been measured in this study and, it is recognized that they can reach much higher concentrations than in blood, correlating better with clinical efficacy.


相关化合物

  • 依托红霉素
  • 琥乙红霉素

相关文献:

Protective effect of Livex, a herbal formulation against erythromycin estolate induced hepatotoxicity in rats.

1998-01-01

[J. Ethnopharmacol. 57(3) , 161-7, (1997)]

Preparation and characterization of biodegradable poly(l-lactide)/poly(ethylene glycol) microcapsules containing erythromycin by emulsion solvent evaporation technique.

2004-03-15

[J. Colloid. Interface Sci. 271(2) , 336-41, (2004)]

Pharmacokinetics of erythromycin estolate and erythromycin phosphate after intragastric administration to healthy foals.

2000-08-01

[Am. J. Vet. Res. 61(8) , 914-9, (2000)]

Five days of erythromycin estolate versus ten days of penicillin V in the treatment of group A streptococcal tonsillopharyngitis in children. Pharyngitis Study Group.

1996-09-01

[Eur. J. Clin. Microbiol. Infect. Dis. 15(9) , 712-7, (1996)]

Multicenter, randomized, double-blind comparison of erythromycin estolate versus amoxicillin for the treatment of acute otitis media in children. AOM Study Group.

1998-07-01

[Eur. J. Clin. Microbiol. Infect. Dis. 17(7) , 470-8, (1998)]

更多文献...