3-(p-Chlorophenyl)-4-aminobutanoic acid--resolution into enantiomers and pharmacological activity.
B Witczuk, R A Khaunina, G Kupryszewski
文献索引:Pol. J. Pharmacol. Pharm. 32 , 187, (1980)
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摘要
Racemic 3-(p-chlorophenyl)-4-aminobutanoic acid was resolved into enantiomers and their absolute configuration determined. Pharmacological activity of hydrochlorides of the racemic acid and its enantiomers has been determined. The R(+) enantiomer was found to be 4.2-9.2-fold as effective as the S(-) one and 1.4-1.9-fold as effective as the racemate.
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