R-(+)-盐酸巴氯芬结构式
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常用名 | R-(+)-盐酸巴氯芬 | 英文名 | (R)-Baclofen (hydrochloride) |
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| CAS号 | 63701-55-3 | 分子量 | 250.12200 | |
| 密度 | N/A | 沸点 | 364.3ºC at 760 mmHg | |
| 分子式 | C10H13Cl2NO2 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 174.1ºC |
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Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat.
Eur. J. Pharmacol. 196 , 267, (1991) In a previous study it was found that i.t. administration of L-baclofen decreased arterial pressure and heart rate while D-baclofen differentially increased arterial pressure. The objective of the present study was to determine which of these effects was bloc... |
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Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations.
J. Neurochem. 47 , 898, (1986) The affinities of a number of analogues of gamma-aminobutyric acid (GABA) for GABAA and GABAB receptor sites and GABA uptake were studied using rat brain membrane preparations. Studies on the (S)-(+)- and (R)-(-)-isomers of baclofen, 3-hydroxy-4-aminobutyric ... |
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3-(p-Chlorophenyl)-4-aminobutanoic acid--resolution into enantiomers and pharmacological activity.
Pol. J. Pharmacol. Pharm. 32 , 187, (1980) Racemic 3-(p-chlorophenyl)-4-aminobutanoic acid was resolved into enantiomers and their absolute configuration determined. Pharmacological activity of hydrochlorides of the racemic acid and its enantiomers has been determined. The R(+) enantiomer was found to... |
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The GABA(B) receptor positive modulator BHF177 attenuated anxiety, but not conditioned fear, in rats.
Neuropharmacology 97 , 357-64, (2015) GABAB (γ-aminobutyric acid B) receptors may be a therapeutic target for anxiety disorders. Here we characterized the effects of the GABAB receptor positive allosteric modulator (PAM) BHF177 on conditioned and unconditioned physiological responses to threat in... |
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Direct inhibition of hypothalamic proopiomelanocortin neurons by dynorphin A is mediated by the μ-opioid receptor.
J. Physiol. 592(Pt 19) , 4247-56, (2014) It has recently been shown that dynorphin A (Dyn A), an endogenous agonist of the κ-opioid receptor (KOR), directly inhibits proopiomelanocortin (POMC) neurons in the hypothalamus through activation of G-protein-coupled inwardly rectifying K(+) channels (GIRK... |