N-甲基苯胺
N-甲基苯胺用途
用作染料中间体
【用途二】
N-甲基苯胺既是杀虫剂噻嗪酮的原料，用于合成其中间体N-氯甲基N-苯基氨基甲酰氯，也是除草剂苯噻酰草胺的中间体，此外还较多地用于染料工业。
【用途三】
该品用作有机合成的中间体、酸吸收剂和溶剂，染料工业中用于阳离子艳红FG、阳离子桃红B、活性黄棕KGR等的生产。
N-甲基苯胺名称
[ CAS 号 ]:
100-61-8
[ 中文名 ]:
N-甲基苯胺
[ 英文名 ]:
N-Methylaniline
[中文别名 ]:
[英文别名 ]:
- N-methyl-aniline
- N-Methylaniline
- N-methylphenylamine
- N-methyl-N-phenylamine
- N-Phenylmethylamine
- MFCD00008283
- Methylaniline
- Monomethylaniline
- EINECS 202-870-9
- N-methyl-aminobenzene
N-甲基苯胺物理化学性质
[ 密度 ]:
1.0±0.1 g/cm3
[ 沸点 ]:
196.2 °C at 760 mmHg
[ 熔点 ]:
−57 °C(lit.)
[ 分子式 ]:
C7H9N
[ 分子量 ]:
107.153
[ 闪点 ]:
78.9 °C
[ 精确质量 ]:
107.073502
[ PSA ]:
12.03000
[ LogP ]:
1.60
[ 外观性状 ]:
淡黄色至棕色液体
[ 蒸汽压 ]:
0.4±0.3 mmHg at 25°C
[ 折射率 ]:
1.573
[ 储存条件 ]:
库房通风低温干燥,与氧化剂、食品化工添加剂分开存放
[ 稳定性 ]:
Stability Combustible. Incompatible with strong oxidizing agents. Discolours upon exposure to air.
[ 水溶解性 ]:
30 g/L
N-甲基苯胺MSDS
N-甲基苯胺毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- BY4550000
- CHEMICAL NAME :
- Aniline, N-methyl-
- CAS REGISTRY NUMBER :
- 100-61-8
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 30
- MOLECULAR FORMULA :
- C7-H9-N
- MOLECULAR WEIGHT :
- 107.17
- WISWESSER LINE NOTATION :
- 1MR
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 24 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis
- REFERENCE :
- JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 31,1,1949
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 280 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis
- REFERENCE :
- JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 31,1,1949
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 24 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis
- REFERENCE :
- JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 31,1,1949
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 1200 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington, DC) Volume(issue)/page/year: 271,16,1941
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 1200 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington, DC) Volume(issue)/page/year: 271,16,1941 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 300 ug/m3/24H/14W-C
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 34(3),7,1969 *** REVIEWS *** ACGIH TLV-TWA 2.2 mg/m3 (0.5 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 2 ppm (9 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,174,1971 OSHA PEL (Gen Indu):8H TWA 2 ppm (9 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 2 ppm (9 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 2 ppm (9 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 2 ppm (9 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 2 ppm (9 mg/m3);Skin JAN 1993 OEL-AUSTRALIA:TWA 0.5 ppm (2 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 0.5 ppm (2.2 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 0.5 ppm (2.25 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 0.5 ppm (2 mg/m3);Skin JAN 1993 OEL-GERMANY:TWA 0.5 ppm (2 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 0.5 ppm (2 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 0.5 ppm (2.2 mg/m3);STEL 1.0 ppm;Skin JAN 1993 OEL-TURKEY:TWA 2 ppm (9 mg/m3);Skin JAN 1993 OEL-UNITED KINGDOM:TWA 0.5 ppm (2 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO MONOMETHYL ANILINE-air:10H TWA 0.5 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3740 No. of Facilities: 82 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 82 (estimated)
N-甲基苯胺安全信息
[ 符号 ]:
GHS06, GHS08, GHS09
[ 信号词 ]:
Danger
[ 危害声明 ]:
H301 + H311 + H331-H373-H410
[ 警示性声明 ]:
P261-P273-P280-P301 + P310-P311-P501
[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
T:Toxic
[ 风险声明 (欧洲) ]:
R23/24/25;R33;R50/53
[ 安全声明 (欧洲) ]:
S28-S36/37-S45-S60-S61-S28A
[ 危险品运输编码 ]:
UN 2294 6.1/PG 3
[ WGK德国 ]:
3
[ RTECS号 ]:
BY4550000
[ 包装等级 ]:
III
[ 危险类别 ]:
6.1
[ 海关编码 ]:
2921420090
N-甲基苯胺合成路线
N-甲基苯胺上下游产品
N-甲基苯胺上游产品
N-甲基苯胺下游产品
N-甲基苯胺制备
1.可有几种方法：将苯胺蒸气与甲醚混合，通过活性氧化铝催化剂，于230-295℃反应制得。苯胺和甲醇在铅锌铬催化剂作用下生成粗品N-甲基苯胺。再经蒸馏脱除甲醇、水、苯胺和N,N-二甲基苯胺而得N-甲基苯胺成品。该反应也可在三氯化磷存在下反应（苯胺：甲醇：三氯化磷=1：0.9：0.003mol）。在实验室制备中，可采用硫酸二甲酯作甲基化剂。将硫酸二甲酯滴加至10%以下的苯胺和水的混合液中，搅拌1h后滴加30%氢氧化钠溶液。静置分取上层有机相，下层用苯提取，提取液回收苯后所得油状物与有机相合并，此即苯胺、N-甲基苯胺和N,N-二甲基苯胺的混合物。用硫酸处理混合物。用硫酸处理混合物，使苯胺生成硫酸盐结晶滤除。N,N-二甲基苯胺可与乙酐经下列反应转化为N-甲基苯胺。工业品N-甲基苯胺含量≥98%。原料消耗定额：苯胺1200kg/t、甲醇700kg/t。
精制方法：用固体氢氧化钾干燥后减压分馏的方法可以除去颜色。由于N-甲基苯胺是由苯胺甲基化制备的，往往含有N,N-二甲基苯胺，靠蒸馏分离比较困难。可将其乙酰化，所得乙酰衍生物重结晶至熔点范围很小(m.p.101~102℃），然后用盐酸水解，减压下蒸馏。
2.将工业品N-甲基苯胺减压蒸馏提纯。
N-甲基苯胺海关
[ 海关编码 ]: 2921420090
[ 中文概述 ]:
2921420090 其他苯胺衍生物及其盐. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
N-甲基苯胺文献
Bioorg. Med. Chem. 17 , 896-904, (2009)
This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoret...
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).J. Med. Chem. 48 , 3269-79, (2005)
Growing interest in the use of both the logarithm of the partition coefficient of the neutral species in the alkane/water system (log P(N)(alk)) and the difference between log P(N)(oct) (the logarithm...
Redox inactive metal ion triggered N-dealkylation by an iron catalyst with dioxygen activation: a lesson from lipoxygenases.Dalton Trans. 44 , 9847-59, (2015)
Utilization of dioxygen as the terminal oxidant at ambient temperature is always a challenge in redox chemistry, because it is hard to oxidize a stable redox metal ion like iron(III) to its high oxida...
相关化工产品/化学物质：
推荐生产厂家/供应商：
公司名：上海吉至生化科技有限公司
区域：上海市奉贤区
价格：
￥138.0/500ml
联系人：刘佳
产品详情：N-甲基苯胺
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥需询单/1mg
￥需询单/1g
￥需询单/1g
￥需询单/1g
联系人：阿拉丁李高志
产品详情：N-甲基苯胺
公司名：西安康诺化工有限公司
区域：西安市雁塔区
价格：
￥需询单/1kg
联系人：高经理
产品详情：N-甲基苯胺
查看所有供应商请点击：
相关化合物
【N-甲基苯胺】化源网提供N-甲基苯胺CAS号100-61-8，N-甲基苯胺MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询N-甲基苯胺上化源网，专业又轻松。>>电脑版：N-甲基苯胺
标题：N-甲基苯胺_MSDS_用途_密度_N-甲基苯胺CAS号【100-61-8】_化源网 地址：https://m.chemsrc.com/mip/cas/100-61-8_830277.html