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吡虫啉-d4

吡虫啉-d4用途

吡虫啉-d4是氘标记的吡虫啉[1]。吡虫啉是一种有效且广泛应用的新烟碱类农药,可用于控制谷物、蔬菜、茶叶和棉花的害虫[2]。

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吡虫啉-d4名称

[ CAS 号 ]:
1015855-75-0

[ 中文名 ]:
吡虫啉-d4

[ 英文名 ]:
imidacloprid d4 (imidazolidin-4,4,5,5 d4)

[中文别名 ]:

吡虫啉-D4

[英文别名 ]:

Imidacloprid-d4
Imidazolidin-4,4,5,5-d4

吡虫啉-d4生物活性

[ 描述 ]:

吡虫啉-d4是氘标记的吡虫啉[1]。吡虫啉是一种有效且广泛应用的新烟碱类农药,可用于控制谷物、蔬菜、茶叶和棉花的害虫[2]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

[体外研究]

氢、碳和其他元素的稳定重同位素已被掺入药物分子中,主要作为药物开发过程中定量的示踪剂。头韵因其可能影响药物的药代动力学和代谢特征而受到关注[1]。

[参考文献]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Kim J, et al. Imidacloprid, a neonicotinoid insecticide, induces insulin resistance. J Toxicol Sci. 2013;38(5):655-60.

吡虫啉-d4物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
442.3±55.0 °C at 760 mmHg

[ 分子式 ]:
C₉H₆ClD₄N₅O₂

[ 分子量 ]:
259.686

[ 闪点 ]:
221.3±31.5 °C

[ 精确质量 ]:
259.077423

[ PSA ]:
86.34000

[ LogP ]:
-0.43

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.706

吡虫啉-d4MSDS

详细MSDS(安全技术说明书)

吡虫啉-d4安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22

[ 危险品运输编码 ]:
NONH for all modes of transport

吡虫啉-d4文献

Simultaneous determination of neonicotinoid insecticides in human serum and urine using diatomaceous earth-assisted extraction and liquid chromatography-tandem mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 969 , 85-94, (2014)

A rapid and sensitive analytical method was developed for simultaneous determination of eight neonicotinoid insecticides (acetamiprid, clothianidin, dinotefuran, flonicamid, imidacloprid, nitenpyram, ...

Biological Monitoring of Human Exposure to Neonicotinoids Using Urine Samples, and Neonicotinoid Excretion Kinetics.

PLoS ONE 11 , e0146335, (2016)

Neonicotinoids, which are novel pesticides, have entered into usage around the world because they are selectively toxic to arthropods and relatively non-toxic to vertebrates. It has been suggested tha...

Widespread occurrence of neonicotinoid insecticides in streams in a high corn and soybean producing region, USA.

Environ. Pollut. 193 , 189-96, (2014)

Neonicotinoid insecticides are of environmental concern, but little is known about their occurrence in surface water. An area of intense corn and soybean production in the Midwestern United States was...

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