2-(2'-羟基乙基氨基)-9-甲基-6-(苄基氨基)嘌呤

用途

Olomoucine 是 ATP 竞争性的 CDKs 的抑制剂。Olomoucine 是一种嘌呤 (HY-34431) 衍生物,可抑制 CDC2/cyclin B, Cdk2/cyclin a, Cdk2/cyclin E (IC50=7 µM),CDK/p35 激酶 (IC50=3 µM) 和 ERK1/p44 MAPK 激酶的活性 (IC50=25 µM)。

点击显示

名称

[ CAS 号 ]:
101622-51-9

[ 中文名 ]:
2-(羟乙氨基)-6-苄氨基-9-甲基嘌呤

[ 英文名 ]:
Olomoucine

[中文别名 ]:

[英文别名 ]:

OLO
olomoucine
MFCD00189360
Olomoucine,high purity

生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 细胞周期/DNA损伤 >> CDK

[ 靶点 ]

cdk2-cyclin A:7 μM (IC50)

cdk2-cyclin E:7 μM (IC50)

[参考文献]

[1]. Vesely, J., Havlicek, J., Strnad, M., et al. Inhibition of cyclin-dependent kinases by purine analogues. European Journal of Biochemistry 224, 771-786 (1994).

[2]. 2.Abraham, R.T., Acquarone, M., Andersen, A., et al. Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. Biology of the Cell 83(2), 105-120 (1995).

物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
579.6±60.0 °C at 760 mmHg

[ 熔点 ]:
120-130 °C

[ 分子式 ]:
C₁₅H₁₈N₆O

[ 分子量 ]:
298.343

[ 闪点 ]:
304.3±32.9 °C

[ 精确质量 ]:
298.154205

[ PSA ]:
87.89000

[ LogP ]:
-0.08

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±1.7 mmHg at 25°C

[ 折射率 ]:
1.691

[ 储存条件 ]:
−20°C

MSDS

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

合成路线

上下游产品

上游产品

下游产品

文献

Inhibition of cyclin-dependent kinases by purine analogues.

Eur. J. Biochem. 224 , 771, (1994)

While testing purines related to the non-specific protein kinase inhibitors N6-dimethylaminopurine and N6-(delta 2-isopentenyl)adenine as potential inhibitors of the p34cdc2/cyclin B kinase, we discov...

Steering neuronal growth cones by shifting the imbalance between exocytosis and endocytosis.

J. Neurosci. 34(21) , 7165-78, (2014)

Extracellular molecular cues guide migrating growth cones along specific routes during development of axon tracts. Such processes rely on asymmetric elevation of cytosolic Ca(2+) concentrations across...

Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases.

Biol. Cell 83 , 105-120, (1995)

Olomoucine (2-(2-hydroxyethylamino)-6-benzylamino-9-methylpurine) has been recently described as a competitive inhibitor (ATP-binding site) of the cell cycle regulating p34cdc2/cyclin B, p33cdk2/cycli...

更多文献

2-(2'-羟基乙基氨基)-9-甲基-6-(苄基氨基)嘌呤

用途

名称

生物活性

物理化学性质

MSDS

详细MSDS(安全技术说明书)

安全信息

合成路线

详细合成路线

上下游产品

上游产品

下游产品

文献

推荐生产厂家/供应商：

相关化合物