2-氨基乙醇

2-氨基乙醇用途

【用途一】
用于除去天然气和石油气中的酸性气体，制造非离子型洗涤剂、乳化剂等
【用途二】
用作气相色谱固定液和溶剂
【用途三】
乙醇胺又名2-氨基乙醇、2-羟基乙胺和单乙醇胺。乙醇胺是制备氨基甲酸酯类杀虫剂双氧威的中间体，还广泛用作从各种气体(如天然气)中提取酸性组分的净化液。由乙醇胺与脂肪酸生成的烷基醇酰胺是有效的泡沫增效剂。乙醇胺还是乳化剂的中间体，用于纺织工业作为抗静电剂、防蛀剂、清洁剂。由乙醇胺盐酸盐环合、中和可制得六水合哌嗪，哌嗪以其磷酸盐或柠檬酸盐的形式可作为驱肠虫药。
【用途四】
GB 2760-96规定为允许使用的食品工业用加工助剂。
【用途五】
一乙醇胺主要用作合成树脂和橡胶的增塑剂、硫化剂、促进剂和发泡剂、以及农药、医药和染料的中间体。也是合成洗涤剂、化妆品的乳化剂等的原料。纺织工业作为印染增白剂、抗静电剂、防蛀剂、清净剂。也可用作二氧化碳吸收剂、油墨助剂、石油添加剂。一乙醇胺广泛用作从各种气体（如天然气）中提取酸性组分的净化液。由一乙醇胺盐酸盐环合、中和可制得六水合哌嗪。一乙醇胺盐酸盐经氯化亚砜氯代，再被硫代硫酸钠取代，可制得β-氨基乙基硫代硫酸盐。这是一种染料中间体，用于生产缩聚翠蓝13G。一乙醇胺与二硫化碳反应可制得在橡胶和制药工业中有应用的中间体硫基噻唑啉。
【用途六】
溶剂。有机合成, 从气体中除去二氧化碳及硫化氢。气相色谱固定液(最高使用温度50℃，溶剂为乙醚)，用于分离低碳醇类、吡啶及其衍生物。

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2-氨基乙醇名称

[ CAS 号 ]:
141-43-5

[ 中文名 ]:
乙醇胺

[ 英文名 ]:
2-Aminoethanol

[中文别名 ]:

[英文别名 ]:

Ethanolamine
amino-2-butanol
mono-sec-butanolamine
2-Butanol,1-amino
MFCD00008183
Monobutanolamine
dl-1-amino-2-butanol
1-Amino-butan-2-ol
2-hydroxybutylamine
2-Aminoethanol

2-氨基乙醇物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
170.9±0.0 °C at 760 mmHg

[ 熔点 ]:
10-11 °C(lit.)

[ 分子式 ]:
C₂H₇NO

[ 分子量 ]:
61.083

[ 闪点 ]:
93.3±0.0 °C

[ 精确质量 ]:
61.052765

[ PSA ]:
46.25000

[ LogP ]:
-1.31

[ 外观性状 ]:
透明液体

[ 蒸汽密度 ]:
2.1 (vs air)

[ 蒸汽压 ]:
0.5±0.7 mmHg at 25°C

[ 折射率 ]:
1.435

[ 储存条件 ]:
包装完整、轻装轻放,库房通风、远离明火、高温、与氧化剂、强酸分开存放

[ 稳定性 ]:
Stable. Flammable; incompatible with strong oxidizing agents, strong acids. Hygroscopic.

[ 水溶解性 ]:
miscible

2-氨基乙醇MSDS

详细MSDS(安全技术说明书)

2-氨基乙醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KJ5775000

CHEMICAL NAME :: Ethanol, 2-amino-

CAS REGISTRY NUMBER :: 141-43-5

LAST UPDATED :: 199806

DATA ITEMS CITED :: 60

MOLECULAR FORMULA :: C2-H7-N-O

MOLECULAR WEIGHT :: 61.10

WISWESSER LINE NOTATION :: Z2Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1720 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 67 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 225 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2420 mg/m3/2H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: >2420 mg/m3/2H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 620 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 115 gm/kg/90D-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 105 mg/kg/30W-I

TOXIC EFFECTS :: Liver - liver function tests impaired Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 66 ppm/24H/30D-C

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Skin and Appendages - dermatitis, irritative (after systemic exposure) Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/m3/5H/26W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression Liver - liver function tests impaired Kidney, Ureter, Bladder - proteinuria

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/m3/5H/26W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - proteinuria Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 102 ppm/24H/30D-C

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Skin and Appendages - dermatitis, irritative (after systemic exposure) Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 75 ppm/24H/24D-C

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Skin and Appendages - dermatitis, irritative (after systemic exposure) Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 500 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 500 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4500 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

DOSE :: 2250 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

REFERENCE :: CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974- Volume(issue)/page/year: 21(6),29,1987 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1996 ACGIH TLV-STEL 15 mg/m3 (6 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 7.5 mg/m3 (3 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 3 ppm (6 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,100,1971 OSHA PEL (Gen Indu):8H TWA 3 ppm (6 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 3 ppm (6 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 3 ppm (6 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 3 ppm (6 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 3 ppm (6 mg/m3) JAN 1993 OEL-AUSTRALIA:TWA 3 ppm (8 mg/m3);STEL 6 ppm (15 mg/m3) JAN 1993 OEL-BELGIUM:TWA 3 ppm (7.5 mg/m3);STEL 6 ppm (15 mg/m3) JAN 1993 OEL-DENMARK:TWA 6 ppm (6 mg/m3) JAN 1993 OEL-FINLAND:TWA 3 ppm (7.5 mg/m3);STEL 6 ppm (15 mg/m3) JAN 1993 OEL-FRANCE:TWA 3 ppm (8 mg/m3) JAN 1993 OEL-GERMANY:TWA 3 ppm (8 mg/m3) JAN 1993 OEL-JAPAN:TWA 3 ppm (7.5 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 3 ppm (8 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 3 ppm (6 mg/m3) JAN 1993 OEL-RUSSIA:TWA 3 ppm;STEL 0.5 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 3 ppm (7.5 mg/m3);STEL 15 ppm (37.5 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 3 ppm (8 mg/m3);STEL 6 ppm (15 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ETHANOLAMINE-air:10H TWA 3 ppm;STEL 6 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 04980 No. of Facilities: 33147 (estimated) No. of Industries: 201 No. of Occupations: 144 No. of Employees: 499260 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 04980 No. of Facilities: 56219 (estimated) No. of Industries: 274 No. of Occupations: 190 No. of Employees: 1163087 (estimated) No. of Female Employees: 328648 (estimated)

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2-氨基乙醇安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302 + H312 + H332-H314-H335-H412

[ 警示性声明 ]:
P261-P273-P301 + P312 + P330-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R20/21/22;R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 2924 3/PG 3

[ WGK德国 ]:
1

[ RTECS号 ]:
KJ5775000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

2-氨基乙醇合成路线

详细合成路线

2-氨基乙醇上下游产品

2-氨基乙醇上游产品

2-氨基乙醇下游产品

2-氨基乙醇制备

1.乙醇胺常存在于磷脂中，并常与胆碱共存，因此也称为胆胺。在血清蛋白腐烂发酵液中也发现有乙醇胺。工业上乙醇胺可由氨与环氧乙烷反应制得。将环氧乙烷、氨水送入反应器中，在反应温度30-40℃，反应压力70.9-304kPa下，进行缩合反应生成一、二、三乙醇胺混合液，在90-120℃下经脱水浓缩后，送入三个减压精馏塔进行减压蒸馏，按不同沸点截取馏分，则可得纯度达99%的一乙醇胺、二乙醇胺和三乙醇胺成品。在反应过程中，如加大环氧乙烷比例，则二、三乙醇胺生成比例增大，可提高二、三乙醇胺的收率。

2.乙醇胺可由氨与环氧乙烷反应制得。
环氧乙烷、氨水溶液和循环氨一起进入不锈钢制成的反应器，内设冷却装置，反应温度30～40℃，反应压力0.7～3MPa。反应产物进入脱氨塔，脱除的氨返回氨吸收器制备氨水溶液，塔底产物经蒸发浓缩和干燥脱水即得粗乙醇胺。采用减压蒸馏将一乙醇胺、二乙醇胺和三乙醇胺分别蒸出，纯度可达到98%~99%，环氧乙烷的转化率接近100%，乙醇胺的收率为95%左右。另外，尚有少量副产物聚醚生成，在原料中配入少量的二氧化碳可以减少副产物的生成。

3.由环氧乙烷和氨水在30～40℃下、70.1～304kPa下缩合而成，其为单、二、三乙醇胺的混合液，在90～120℃下脱水、浓缩，然后于精馏塔中减压蒸馏，截取168～174℃馏分而得。

精制方法：易含杂质有水、乙二醇、二乙醇胺、三乙醇胺等。常压下蒸馏时部分发生分解，可在减压下(约0.667KPa）反复分馏精制。分馏时注意防止吸收二氧化碳。馏出物用乙醚洗涤，乙醇重结晶后可得纯品。

4.乙醇胺的制备采用环氧乙烷氨化工艺，可分为连续和间歇两种方法，同时可得到一乙醇胺、二乙醇胺和三乙醇胺三种产品。通常采用改变氨与环氧乙烷的物质的量的比来调整三种产品的产出量。在连续生产过程中，原料氨和环氧乙烷经管式反应器反应后，再经脱氨塔、脱水塔和蒸馏塔进行脱氨、脱水和减压精馏处理，即可分别得到一乙醇胺、二乙醇胺和三乙醇胺成品。

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2-氨基乙醇文献

Binding properties of antimicrobial agents to lipid membranes using surface plasmon resonance.

Biol. Pharm. Bull. 37(8) , 1383-9, (2014)

In the present study, we examined the interaction of antimicrobial agents with four model lipid membranes that mimicked mammalian cell membranes and Gram-positive and -negative bacterial membranes and...

Positive cooperativity between acceptor and donor sites of the peptidoglycan glycosyltransferase.

Biochem. Pharmacol. 93(2) , 141-50, (2015)

The glycosyltransferases of family 51 (GT51) catalyze the polymerization of lipid II to form linear glycan chains, which, after cross linking by the transpeptidases, form the net-like peptidoglycan ma...

Investigation of the interactions between the EphB2 receptor and SNEW peptide variants.

Growth Factors 32(6) , 236-46, (2014)

EphB2 interacts with cell surface-bound ephrin ligands to relay bidirectional signals. Overexpression of the EphB2 receptor protein has been linked to different types of cancer. The SNEW (SNEWIQPRLPQH...

更多文献

2-氨基乙醇

2-氨基乙醇用途

2-氨基乙醇名称

2-氨基乙醇物理化学性质

2-氨基乙醇MSDS

详细MSDS(安全技术说明书)

2-氨基乙醇毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

2-氨基乙醇安全信息

2-氨基乙醇合成路线

详细合成路线

2-氨基乙醇上下游产品

2-氨基乙醇上游产品

2-氨基乙醇下游产品

2-氨基乙醇制备

2-氨基乙醇文献

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