奈立索泮
奈立索泮名称
[ CAS 号 ]:
102771-12-0
[ 中文名 ]:
奈立索泮
[ 英文名 ]:
Nerisopam
[英文别名 ]:
- UNII-18Q4O339AG
- Nerisopam
- Nerisopam [INN]
奈立索泮物理化学性质
[ 密度 ]:
1.22g/cm3
[ 沸点 ]:
475.4ºC at 760mmHg
[ 分子式 ]:
C18H19N3O2
[ 分子量 ]:
309.36200
[ 闪点 ]:
241.3ºC
[ 精确质量 ]:
309.14800
[ PSA ]:
69.20000
[ LogP ]:
2.50780
[ 蒸汽压 ]:
3.34E-09mmHg at 25°C
[ 折射率 ]:
1.612
奈立索泮毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DE8746050
- CHEMICAL NAME :
- 5H-2,3-Benzodiazepine, 1-(4-aminophenyl)-7,8-dimethoxy-4-methyl-
- CAS REGISTRY NUMBER :
- 102771-12-0
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C18-H19-N3-O2
- MOLECULAR WEIGHT :
- 309.40
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 128 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 39,894,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 108 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 39,894,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 275 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 39,894,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 182 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 39,894,1989
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