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奈立膦酸

奈立膦酸用途

Neridronate 是一种氨基二膦酸盐,用于治疗成骨不全症 (OI) 和佩吉特骨病(PDB)。Neridronate 对其他骨骼疾病也有效,如骨质疏松症,骨痛退化症,恶性高钙血症和骨转移病变。

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奈立膦酸名称

[ CAS 号 ]:
79778-41-9

[ 中文名 ]:
奈立膦酸

[ 英文名 ]:
Neridronate

[英文别名 ]:

Neridronic
6-amino-1-hydroxyhexane-1,1-diphosphonic acid
NERIXIA
6-amino-1-hydroxy-1,1-hexylidenebisphosphonic acid
Phosphonic acid, (6-amino-1-hydroxyhexylidene)bis-
(6-amino-1-hydroxyhexylidene)bisphosphonate
6-AMINO-1-HYDROXYHEXYLIDENE BISPHOSPHONIC ACID
6-amino-1-hydroxyhexane-1,1-diphosphonate
NERIDRONATE
Neridronic acid

奈立膦酸生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Gatti D, et al. Clinical development of neridronate: potential for new applications. Ther Clin Risk Manag. 2013;9:139-47.

[2]. Guiducci L, et al. Monthly Intramuscular Neridronate for the Treatment of Postmenopausal Osteoporosis: Results of a 6-Year Prospective Italian Study. Int J Endocrinol. 2019 Feb 6;2019:9802827.

奈立膦酸物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
600.1±65.0 °C at 760 mmHg

[ 熔点 ]:
245°

[ 分子式 ]:
C₆H₁₇NO₇P₂

[ 分子量 ]:
277.149

[ 闪点 ]:
316.7±34.3 °C

[ 精确质量 ]:
277.048035

[ PSA ]:
180.93000

[ LogP ]:
-3.36

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±3.9 mmHg at 25°C

[ 折射率 ]:
1.569

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
H2O: 8 mg/mL, soluble

奈立膦酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

奈立膦酸合成路线

详细合成路线

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奈立膦酸文献

Bisphosphonate protonation states, conformations, and dynamics on bone mineral probed by solid-state NMR without isotope enrichment.

Eur. J. Pharm. Biopharm. 76(1) , 120-6, (2010)

Recognition of bone mineral by bisphosphonates is crucial to their targeting, efficacy, therapeutic and diagnostic applications, and pharmacokinetics. In a search for rapid and simple NMR approaches t...

Intramuscular neridronate in postmenopausal women with low bone mineral density.

Calcif. Tissue Int. 83(5) , 301-7, (2008)

Compliance to osteoporosis treatment with oral bisphosphonates is very poor. Intermittent intravenous bisphosphonate is a useful alternative, but this route is not readily available. Neridronate, a ni...

The use of intravenous aminobisphosphonates for the treatment of Paget's disease of bone.

Mini Rev. Med. Chem. 9(9) , 1052-63, (2009)

Mycophenolic acid (MPA) is the active metabolite of mycophenolate mofetil, a widely used immunosuppressant. Numerous studies have developed limited sampling strategies (LSSs) to predict MPA AUC in sol...

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