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[D-p-Cl-Phe6,Leu17]-VIP

[D-p-Cl-Phe6,Leu17]-VIP用途

[D-p-Cl-Phe6,Leu17]-VIP 是一种竞争性和选择性的血管活性肠肽 (VIP) 受体拮抗剂,IC50 值为 125.8 nM。[D-p-Cl-Phe6,Leu17]-VIP 对胰高血糖素,促胰液素和 GRF 受体无活性。

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[D-p-Cl-Phe6,Leu17]-VIP名称

[ CAS 号 ]:
102805-45-8

[ 中文名 ]:
[D-p-Cl-Phe6, Leu17]-七磷酸庚糖血管活性肠肽,三氟乙酸盐

[ 英文名 ]:
(p-Chloro-D-Phe6,Leu17)-VIP (human, mouse, rat) trifluoroacetate salt

[英文别名 ]:

(p-Chloro-D-Phe6,Leu17)-VIP
[4ClDPhe6,Leu17] VIP

[D-p-Cl-Phe6,Leu17]-VIP生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

研究领域 >> 神经疾病

[ 靶点 ]

IC50: 125.8 nM (VIP receptor)[1]

[参考文献]

[1]. Pozo D, et, al. Characterization of VIP receptor-effector system antagonists in rat and mouse peritoneal macrophages. Eur J Pharmacol. 1997 Mar 5; 321(3): 379-86.

[2]. Pandol SJ, et, al. Vasoactive intestinal peptide receptor antagonist [4Cl-D-Phe6, Leu17] VIP. Am J Physiol. 1986 Apr; 250 (4 Pt 1): G553-7.

[3]. Messmer B, et, al. Regulation of exocrine pancreatic secretion by cerebral TRH and CGRP: role of VIP, muscarinic, and adrenergic pathways. Am J Physiol. 1993 Feb; 264(2 Pt 1): G237-42.

[D-p-Cl-Phe6,Leu17]-VIP物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 分子式 ]:
C₁₄₈H₂₃₉ClN₄₄O₄₂

[ 分子量 ]:
3342.204

[ 精确质量 ]:
3339.760742

[ PSA ]:
1453.69000

[ LogP ]:
-4.01

[ 折射率 ]:
1.657

[ 储存条件 ]:
-20°C

[D-p-Cl-Phe6,Leu17]-VIP安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[D-p-Cl-Phe6,Leu17]-VIP文献

Vasoactive intestinal polypeptide antagonists attenuate vagally induced tachycardia in the anesthetized dog.

Am. J. Physiol. 269(4 Pt 2) , H1467-72, (1995)

We used three vasoactive intestinal polypeptide (VIP) antagonists, VIP-(10-28), [p-Cl-D-Phe6,Leu17]VIP, and NT-VIP, to evaluate the role of VIP as a mediator of vagally induced tachycardia in chloralo...

Pituitary adenylate cyclase-activating peptide stimulates cyclic AMP accumulation in UMR 106 osteoblast-like cells.

J. Endocrinol. 149 , 287, (1996)

Pituitary adenylate cyclase-activating peptide (PACAP) and vasoactive intestinal peptide (VIP) share 68% homology and function as neurotransmitters or neuroendocrine factors. Although VIP immunoreacti...

Vagal nerve stimulation increases right ventricular contraction and relaxation and heart rate.

Cardiovasc. Res. 32(5) , 846-53, (1996)

To determine the effects of vasoactive intestinal peptide, released from the right and left vagal nerves, on ventricular contraction, relaxation, and heart rate.The muscarinic and beta-adrenergic rece...

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