对甲氧基苯胺

对甲氧基苯胺用途

【用途一】
用作染料和医药中间体
【用途二】
用作测定高铁的络合指示剂，也用于有机合成
【用途三】
该品主要用于染料工业，制取冰染染料，是枣红色基GP、蓝色盐VB、色酚AS-RL、色酚AS-SG、C.I.分散蓝79等染料和消炎痛、阿的平、伯喹等医药的中间体。

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对甲氧基苯胺名称

[ CAS 号 ]:
104-94-9

[ 中文名 ]:
对甲氧基苯胺

[ 英文名 ]:
p-Anisidine

[中文别名 ]:

[英文别名 ]:

p-ansidine
para-methoxyaniline
p-Methoxyphenylamine
4-Methoxyaniline
4-Methoxybenzenamine
4-Aminoanisole
4-Methoxy-phenylamine
1-Amino-4-methoxybenzene
Anisidine
aniline, 4-methoxy-

对甲氧基苯胺物理化学性质

[ 密度 ]:
1.06

[ 沸点 ]:
240-243 ºC

[ 熔点 ]:
56-59 °C(lit.)

[ 分子式 ]:
C₇H₉NO

[ 分子量 ]:
123.152

[ 闪点 ]:
122 ºC

[ 精确质量 ]:
123.068413

[ PSA ]:
35.25000

[ LogP ]:
0.74

[ 外观性状 ]:
白色,熔化的结晶固体,特有的胺气味

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.555

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 水溶解性 ]:
21 g/L (20 ºC)

对甲氧基苯胺MSDS

对甲氧基苯胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BZ5450000

CHEMICAL NAME :: p-Anisidine

CAS REGISTRY NUMBER :: 104-94-9

LAST UPDATED :: 199712

DATA ITEMS CITED :: 43

MOLECULAR FORMULA :: C7-H9-N-O

MOLECULAR WEIGHT :: 123.17

WISWESSER LINE NOTATION :: ZR DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1410 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 806 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2900 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes Blood - normocytic anemia Blood - other changes

TYPE OF TEST :: DNA inhibition

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.5 mg/m3 (0.1 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,63,1982 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.1 ppm (0.5 mg/m3) (skin) DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. Volume(issue)/page/year: 3,10,1973 OSHA PEL (Gen Indu):8H TWA 0.5 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.5 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.5 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.5 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.1 ppm (0.5 mg/m3);Skin JAN 1993 OEL-AUSTRIA:TWA 0.1 ppm (0.5 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 0.1 ppm (0.5 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 0.1 ppm (0.5 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 0.5 mg/m3;STEL 1.5 mg/m3;Skin;Carcinogen JAN 1993 OEL-FRANCE:TWA 0.1 ppm (0.5 mg/m3);Skin;Carcinogen JAN 1993 OEL-GERMANY:TWA 0.1 ppm (0.5 mg/m3);Skin JAN 1993 OEL-INDIA:TWA 0.1 ppm (0.5 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 0.1 ppm (0.5 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 0.5 mg/m3;Skin JAN 1993 OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 0.1 ppm (0.5 mg/m3);STEL 0.2 ppm;Skin JAN 1993 OEL-UNITED KINGDOM:TWA 0.1 ppm (0.5 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO p-ANISIDINE-air:10H TWA 0.5 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992

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对甲氧基苯胺安全信息

[ 符号 ]:

GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H310-H330-H350-H373-H400

[ 警示性声明 ]:
P201-P260-P273-P280-P284-P301 + P310

[ 危害码 (欧洲) ]:
T+:Verytoxic;N:Dangerous for the environment;

[ 风险声明 (欧洲) ]:
R26/27/28;R33;R45;R50

[ 安全声明 (欧洲) ]:
S53-S28-S36/37-S45-S61-S28A

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
BZ5450000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29222200

对甲氧基苯胺合成路线

对甲氧基苯胺上下游产品

对甲氧基苯胺上游产品

对甲氧基苯胺下游产品

对甲氧基苯胺制备

1、传统硫化钠法原料对硝基氯苯与甲醇；液碱进行甲氧基化反应，生成对硝基苯甲醚，用硫化钠还原对硝基苯甲醚，反应产物经分离；减压蒸馏后，得成品对氨基苯甲醚。在还原锅加入23%的硫化钠，搅拌加热至90℃，在4h内加入对硝基苯甲醚，加料温度控制在90-95℃。加完后，升温至100℃搅拌0.5h，升温至110-111℃搅拌2h，分去废水，减压蒸馏，得对甲氧基苯胺。
原料消耗定额：对硝基氯苯1348kg/t；甲醇398kg/t；固碱367kg/t；硫化碱1102kg/t。

2、催化加氢还原法国外普遍采用加氢还原法生产对氨基苯甲醚，我国也正着手试验加氢还原新工艺。

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对甲氧基苯胺海关

[ 海关编码 ]: 2922291000

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922291000 4-methoxyaniline。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:6.5%。General tariff:30.0%

对甲氧基苯胺文献

cIEF for rapid pKa determination of small molecules: a proof of concept.

Eur. J. Pharm. Sci. 63 , 14-21, (2014)

A capillary isoelectric focusing (cIEF) method was developed for the determination of the ionization constants (pKa) of small molecules. Two approaches used to decrease the electroosmotic flow (EOF) w...

Antioxidant Properties of Aqueous Extract of Roasted Hulled Barley in Bulk Oil or Oil-in-Water Emulsion Matrix.

J. Food Sci. 80 , C2382-8, (2015)

Antioxidant properties of the aqueous extracts of hulled barley (Hordeum vulgare L.) that had been roasted at 210 °C for 20 min were determined in bulk oil and oil-in-water (O/W) emulsions. Bulk oils ...

Design and synthesis of a novel pre-column derivatization reagent with a 6-methoxy-4-quinolone moiety for fluorescence and tandem mass spectrometric detection and its application to chiral amino acid analysis.

J. Pharm. Biomed. Anal. 116 , 71-9, (2015)

A new pre-column derivatization reagent with a 6-methoxy-4-quinolone (6-MOQ) moiety for amino acid analysis, 2,5-dioxopyrrolidin-1-yl(2-(6-methoxy-4-oxoquinolin-1(4H)-yl)ethyl) carbonate (6-MOQ-EtOCOO...

更多文献

对甲氧基苯胺

对甲氧基苯胺用途

对甲氧基苯胺名称

对甲氧基苯胺物理化学性质

对甲氧基苯胺MSDS

详细MSDS(安全技术说明书)

对甲氧基苯胺毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

对甲氧基苯胺安全信息

对甲氧基苯胺合成路线

详细合成路线

对甲氧基苯胺上下游产品

对甲氧基苯胺上游产品

对甲氧基苯胺下游产品

对甲氧基苯胺制备

对甲氧基苯胺海关

对甲氧基苯胺文献

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