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N,O-双(三甲基硅基)乙酰胺

N,O-双(三甲基硅基)乙酰胺用途

【用途一】
医药中间体，中性硅烷化保护剂，主要用于合成头孢类抗生素
【用途二】
用于制备头孢类药物
【用途三】
是制备头孢类药物的保护剂
【用途四】
中性硅烷化保护剂，BSA产品是重要的医药中间体，主要用于合成孢头抗生素的生产。

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N,O-双(三甲基硅基)乙酰胺名称

[ CAS 号 ]:
10416-59-8

[ 中文名 ]:
N,O-双三甲硅基乙酰胺

[ 英文名 ]:
N,O-Bis(trimethylsilyl)acetamide

[中文别名 ]:

[英文别名 ]:

TMS-BABSA
bsa kit
EINECS 233-892-7
tms-ba kit
MFCD00008270
N,O-Bis(trimethylsilyl)acetamide
TMS-BA
Trimethylsilyl N-(trime
TMS-BA KitBSA Kit
CB2500

N,O-双(三甲基硅基)乙酰胺物理化学性质

[ 密度 ]:
0.8±0.1 g/cm3

[ 沸点 ]:
162.1±0.0 °C at 760 mmHg

[ 熔点 ]:
24 °C

[ 分子式 ]:
C₈H₂₁NOSi₂

[ 分子量 ]:
203.429

[ 闪点 ]:
65.5±22.6 °C

[ 精确质量 ]:
203.116165

[ PSA ]:
21.59000

[ LogP ]:
3.16

[ 外观性状 ]:
透明至淡黄色透明液体

[ 蒸汽压 ]:
2.9±0.3 mmHg at 25°C

[ 折射率 ]:
1.411

[ 储存条件 ]:
0-6°C

[ 水溶解性 ]:
可溶于：苯,二氯甲烷,乙醚

N,O-双(三甲基硅基)乙酰胺MSDS

N,O-双(三甲基硅基)乙酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AK3000000

CHEMICAL NAME :: Acetimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester

CAS REGISTRY NUMBER :: 10416-59-8

LAST UPDATED :: 199707

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H21-N-O-Si2

MOLECULAR WEIGHT :: 203.48

WISWESSER LINE NOTATION :: 1-SI-1&1&OY1&UN-SI-1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Immunological Including Allergic - decreased immune response

REFERENCE :: StoGD# Personal Communication from G.D. Stoner, Dept. of Community Medicine, School of Medicine, Univ. of California, La Jolla, CA 92037, May 25, 1975 Volume(issue)/page/year: 27MAY1975 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg/I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

REFERENCE :: JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 54,495,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7061 No. of Facilities: 10 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 226 (estimated) No. of Female Employees: 151 (estimated)

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N,O-双(三甲基硅基)乙酰胺安全信息

[ 符号 ]:

GHS02, GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H226-H302-H314

[ 补充危害声明 ]:
Reacts violently with water.

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R10;R14;R22;R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S7/8-S43A-S36-S30

[ 危险品运输编码 ]:
UN 2920 8/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
AK3000000

[ 包装等级 ]:
II

[ 危险类别 ]:
8

[ 海关编码 ]:
29310095

N,O-双(三甲基硅基)乙酰胺合成路线

N,O-双(三甲基硅基)乙酰胺上下游产品

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N,O-双(三甲基硅基)乙酰胺海关

[ 海关编码 ]: 2931900090

[ 中文概述 ]:
2931900090. 其他有机-无机化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:6.5%. 普通关税:30.0%

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

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