Phenylacetic acid mustard

Phenylacetic acid mustard用途

Phenylacetic acid mustard 是化疗试剂 Chlorambucil (HY-13593) 的主要代谢产物 (metabolite)。Chlorambucil 是一种烷化剂 (alkylator),具有抗肿瘤活性。

点击显示

Phenylacetic acid mustard名称

[ CAS 号 ]:
10477-72-2

[ 英文名 ]:
Phenylacetic acid mustard

[英文别名 ]:

PAAM
Chlorphenacyl
Phenylacetic acid mustard
Khlorfenatsil
Chlorphenacil
Phenacid
Phenylacetic mustard

Phenylacetic acid mustard生物活性

[ 描述 ]:

Phenylacetic acid mustard 是化疗试剂 Chlorambucil (HY-13593) 的主要代谢产物 (metabolite)。Chlorambucil 是一种烷化剂 (alkylator),具有抗肿瘤活性。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> DNA烷基化剂/交联剂

[ 靶点 ]

IC50: metabolite of Chlorambucil[1]

[体内研究]

苯乙酸芥末(腹腔注射；0-20 mg/kg；15天)的抗肿瘤能力始终比CHL高1.8-1.9倍,ED15值为8.0 mg/kg[2]。苯乙酸芥末(腹腔注射；0-20毫克/公斤；单次剂量)在剂量15.9毫克/公斤时造成50%的致死率[2]。动物模型：雄性近交系C3H/He小鼠[1]剂量：0 mg/kg；5 mg/kg；10 mg/kg；20 mg/kg；腹腔注射；15天结果：体内有抗肿瘤活性。

[参考文献]

[1]. Toni Pettersson-Fernholm, et al. Reactions of 4-bis(2-chloroethyl)aminophenylacetic acid (phenylacetic acid mustard) in physiological solutions.

[2]. F Y Lee, et al. Pharmacokinetic basis for the comparative antitumour activity and toxicity of chlorambucil, phenylacetic acid mustard and, -difluorochlorambucil (CB 7103) in mice.

Phenylacetic acid mustard物理化学性质

[ 沸点 ]:
195.5ºC at 760 mmHg

[ 分子式 ]:
C₁₂H₁₅Cl₂NO₂

[ 分子量 ]:
276.15900

[ 闪点 ]:
89.6ºC

[ 精确质量 ]:
275.04800

[ PSA ]:
40.54000

[ LogP ]:
2.59770

[ 蒸汽压 ]:
0.418mmHg at 25°C

Phenylacetic acid mustard毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AF5456000

CHEMICAL NAME :: Acetic acid, 2-(p-(bis(2-chloroethyl)amino)phenyl)-

CAS REGISTRY NUMBER :: 10477-72-2

BEILSTEIN REFERENCE NO. :: 0960062

LAST UPDATED :: 199612

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C12-H15-Cl2-N-O2

MOLECULAR WEIGHT :: 276.18

WISWESSER LINE NOTATION :: QV1R DN2G2G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15900 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 10 mg/kg

SEX/DURATION :: female 14 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - ovaries, fallopian tubes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 8 mg/kg

SEX/DURATION :: male 14 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Rodent - hamster Fibroblast

DOSE/DURATION :: 1500 umol/L

REFERENCE :: BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956- Volume(issue)/page/year: 92,943,1981

点击显示

Phenylacetic acid mustard安全信息

[ 海关编码 ]:
2922499990

Phenylacetic acid mustard合成路线

详细合成路线

Phenylacetic acid mustard上下游产品

Phenylacetic acid mustard上游产品

Phenylacetic acid mustard下游产品

Phenylacetic acid mustard海关

[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%