对氯甲苯
对氯甲苯用途
用作染料中间体和溶剂，也用于有机合成
【用途二】
主要用于生产对氯次苄基三氟，也用于制造对氯苄基氯、对氯苯甲醛、对氯苯甲酰氯、对氯苯甲酸等，也用于医药
【用途三】
对氯甲苯是制造氰戊菊酯、多效唑、烯效唑和氟乐灵、禾草丹、杀草隆等农药的中间体；也可以制造对氯苯甲醛，用作染料和医药中间体；制造对氯苯甲酰氯，是医药消炎通的中间体；制造对氯苯甲酸，为染料和纺织整理剂的原料。
【用途四】
有机合成原料。合成医药、农药和染料的中间体，如合成乙胺嘧啶，芬那露的中间体，也用作溶剂。
【用途五】
溶剂。有机合成。 用于农药、医药、染料等，如作医药“消炎痛”的中间体，农药“氰戊菊酯”、“氟氯灵”、“杀草丹”等原料，也作橡胶、合成树脂的溶剂。
对氯甲苯名称
[ CAS 号 ]:
106-43-4
[ 中文名 ]:
对氯甲苯
[ 英文名 ]:
4-Chlorotoluene
[中文别名 ]:
[英文别名 ]:
- P-CHLOROTOLUENE
- 4-methyl-chlorobenzene
- 1-chloro-4-methylbenzeene
- 4-Chlorotoluene
- EINECS 203-397-0
- 1-Chloro-4-methyl-benzene
- 4-chloro-1-methyl-anthraquinone
- 4-Methylchlorobenzene
- 1-Methyl-4-chlor-anthrachinon
- 1-chloro-4-methyl-9,10-anthraquinone
对氯甲苯物理化学性质
[ 密度 ]:
1.1±0.1 g/cm3
[ 沸点 ]:
162 ºC
[ 熔点 ]:
6-8 °C(lit.)
[ 分子式 ]:
C7H7Cl
[ 分子量 ]:
126.584
[ 闪点 ]:
49 ºC
[ 精确质量 ]:
126.023628
[ LogP ]:
3.27
[ 外观性状 ]:
透明液体
[ 蒸汽密度 ]:
4.38 (vs air)
[ 蒸汽压 ]:
3.4±0.3 mmHg at 25°C
[ 折射率 ]:
1.524
[ 储存条件 ]:
库房通风低温干燥,轻装轻卸、与氧化剂和酸类分开存放
[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.
[ 水溶解性 ]:
<0.1 g/100 mL at 20 ºC
对氯甲苯MSDS
对氯甲苯毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XS9010000
- CHEMICAL NAME :
- Toluene, p-chloro-
- CAS REGISTRY NUMBER :
- 106-43-4
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 14
- MOLECULAR FORMULA :
- C7-H7-Cl
- MOLECULAR WEIGHT :
- 126.59
- WISWESSER LINE NOTATION :
- GR D1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2100 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - cyanosis Gastrointestinal - changes in structure or function of salivary glands
- REFERENCE :
- TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460) Volume(issue)/page/year: OTS0513162
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(12),64,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1900 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,38,1982
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 34 gm/m3/2H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,38,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - excitement Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 46(2),67,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 3750 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - excitement Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 46(2),67,1981 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 182 mg/kg/26W-I
- TOXIC EFFECTS :
- Brain and Coverings - recordings from specific areas of CNS Liver - hepatitis (hepatocellular necrosis), zonal Liver - liver function tests impaired
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 46(2),67,1981
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 25200 mg/kg/2W-I
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
- REFERENCE :
- JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 9(5),487,1990
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 72 gm/kg/90D-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Endocrine - changes in adrenal weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
- REFERENCE :
- JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 9(5),487,1990 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 mg/m3 JAN 1993
对氯甲苯安全信息
[ 符号 ]:
GHS02, GHS07, GHS09
[ 信号词 ]:
Warning
[ 危害声明 ]:
H226-H317-H332-H411
[ 警示性声明 ]:
P273-P280
[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
Xn:Harmful
[ 风险声明 (欧洲) ]:
R20;R51/53
[ 安全声明 (欧洲) ]:
S24/25-S61-S45-S36/37-S16-S7
[ 危险品运输编码 ]:
UN 2238 3/PG 3
[ WGK德国 ]:
2
[ RTECS号 ]:
XS9010000
[ 包装等级 ]:
III
[ 危险类别 ]:
3
[ 海关编码 ]:
29337900
对氯甲苯合成路线
对氯甲苯上下游产品
对氯甲苯上游产品
对氯甲苯下游产品
对氯甲苯制备
其制备方法有以下几种。
1.重氮化法
在反应釜中加入工业用盐酸和对甲基苯胺，釜内温度降至0℃，使对甲基苯胺生成盐酸盐，搅拌，加入亚硝酸钠溶液，使其发生重氮化反应，温度维持在0～5℃，时间约30min，重氮化反应完成后，将其加入到搅拌的氯化亚铜溶液中，逐渐升温到室温，在室温下搅拌2.5～3h，再加热到60℃，该反应物逐步分解成为氮气和对氯甲苯，然后用水蒸气蒸馏，收集对氯甲苯与水的混合液，进行分层，有机层用酸洗涤，再用水洗涤，干燥，进行蒸馏，收集158～162℃馏分为对氯甲苯，收率约70％～79％。
2.直接氯化法
经食盐干燥脱水的甲苯经计量槽计量后进入甲苯氯化反应器，计量后的氯气由反应器的底部通入，甲苯与氯气在一定温度下，以三氯化铁为催化剂进行苯环氯化，生成一氯甲苯氯化液，该氯化液用氮气赶去余气和氯化氢，再进行粗蒸，得到对氯甲苯和邻氯甲苯的混合物，其对、邻比随着催化剂和反应条件不同而不同，一般对、邻比为55∶45。
对氯甲苯和邻氯甲苯的分离可用精馏法、分子筛吸附法、精馏结晶联合法等。精馏结晶联合法，能耗较低，得到的对氯甲苯和邻氯甲苯含量均较高，如采用降膜冷冻结晶法，对氯甲苯的含量可达99％以上。
对氯甲苯海关
[ 海关编码 ]: 2903991000
[ 中文概述 ]:
2903991000 对氯甲苯。监管条件:无。增值税率:17.0%。退税率:9.0%。最低关税:5.5%。普通关税:30.0%
[ Summary ]:
2903991000 1-chloro-4-methylbenzene。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:5.5%。General tariff:30.0%
对氯甲苯文献
Eur. J. Med. Chem. 43 , 714-40, (2008)
Simplified molecular input line entry system (SMILES) has been utilized in constructing quantitative structure-property relationships (QSPR) for octanol/water partition coefficient of vitamins and org...
Optimizations of packed sorbent and inlet temperature for large volume-direct aqueous injection-gas chromatography to determine high boiling volatile organic compounds in water.J. Chromatogr. A. 1356 , 221-9, (2014)
For the expanded application area, fast trace analysis of certain high boiling point (i.e., 150-250 °C) volatile organic compounds (HVOCs) in water, a large volume-direct aqueous injection-gas chromat...
Mechanism-Based Post-Translational Modification and Inactivation in Terpene Synthases.ACS Chem. Biol. 10 , 2501-11, (2015)
Terpenes are ubiquitous natural chemicals with diverse biological functions spanning all three domains of life. In specialized metabolism, the active sites of terpene synthases (TPSs) evolve in shape ...
相关化工产品/化学物质：
推荐生产厂家/供应商：
公司名：上海吉至生化科技有限公司
区域：上海市奉贤区
价格：
￥138.0/500ml
联系人：刘佳
产品详情：对氯甲苯
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥106.0/1g
￥需询单/1g
￥需询单/1g
￥需询单/1g
联系人：阿拉丁
产品详情：对氯甲苯
查看所有供应商请点击：
相关化合物
【对氯甲苯】化源网提供对氯甲苯CAS号106-43-4，对氯甲苯MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询对氯甲苯上化源网，专业又轻松。>>电脑版：对氯甲苯
标题：对氯甲苯_MSDS_用途_密度_对氯甲苯CAS号【106-43-4】_化源网 地址：https://m.chemsrc.com/mip/cas/106-43-4_237509.html