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Alpha-氰基-(3-乙氧基-4-羟基-5-苯基硫代甲基)肉桂酰胺

用途

ST638是一种有效的酪氨酸激酶抑制剂,IC50为370nm[1]。

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名称

[ CAS 号 ]:
107761-24-0

[ 中文名 ]:
Alpha-氰基-(3-乙氧基-4-羟基-5-苯基硫代甲基)肉桂酰胺

[ 英文名 ]:
ST638

[中文别名 ]:

[英文别名 ]:

MFCD00236446
ST638 (pharmaceutical)
ST 638

生物活性

[ 描述 ]:

ST638是一种有效的酪氨酸激酶抑制剂,IC50为370nm[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. Fuortes M, et al. Adhesion-dependent protein tyrosine phosphorylation in neutrophils treated with tumor necrosis factor. J Cell Biol. 1993 Feb;120(3):777-84.

物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
611.2±55.0 °C at 760 mmHg

[ 熔点 ]:
134-135.5ºC

[ 分子式 ]:
C₁₉H₁₈N₂O₃S

[ 分子量 ]:
354.423

[ 闪点 ]:
323.5±31.5 °C

[ 精确质量 ]:
354.103821

[ PSA ]:
121.64000

[ LogP ]:
2.34

[ 蒸汽压 ]:
0.0±1.8 mmHg at 25°C

[ 折射率 ]:
1.656

MSDS

详细MSDS(安全技术说明书)

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UC6316200

CHEMICAL NAME :: 2-Propenamide, 2-cyano-3-(3-ethoxy-4-hydroxy-5-((phenylthio)methyl)p henyl)-

CAS REGISTRY NUMBER :: 107761-24-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C19-H18-N2-O3-S

MOLECULAR WEIGHT :: 354.45

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #93-00938

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #93-00938

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安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
UC6316200

[ 海关编码 ]:
2930909090

海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

文献

The effect of a naphthalene derivative, TEI-6472, on histamine release and tyrosine phosphorylation in rat basophilic leukemia cells.

Int. J. Immunopharmacol. 17(5) , 433-41, (1995)

It is well known that rat basophilic leukemia cells (RBL-2H3) express high-affinity IgE receptors (Fc epsilon RI) and that the aggregation of these receptors causes the release of chemical mediators. ...

Inhibition of fast sodium current in rabbit ventricular myocytes by protein tyrosine kinase inhibitors.

Pflugers Arch. 446(4) , 485-91, (2003)

The present study investigated the effects of protein tyrosine kinase inhibitors on the fast sodium current ( I(Na)) in rabbit ventricular myocytes. Single rabbit ventricular myocytes were isolated en...

Involvement of phosphatidic acid in both degranulation and oxidative activity in fMet-Leu-Phe stimulated polymorphonuclear leukocytes.

Cell Physiol. Biochem. 13(3) , 165-72, (2003)

Polymorphonuclear leukocytes (neutrophils) release a variety of toxic agents--proteins and reactive oxygen species (ROS)--that are used to inactivate foreign microorganisms in the non-specific immune ...

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