3-羟基丙腈
3-羟基丙腈用途
用作医药、有机合成中间体
【用途二】
用作纤维素酯类及许多无机盐的溶剂，经加氢可得3-氨基丙醇，用于药物环磷酰胺、心得安等的合成。
3-羟基丙腈名称
[ CAS 号 ]:
109-78-4
[ 中文名 ]:
3-羟基丙腈
[ 英文名 ]:
hydracrylonitrile
[中文别名 ]:
[英文别名 ]:
- MFCD00002826
- β-Hydroxypropionitrile
- Propanenitrile, 3-hydroxy-
- 3-Hydroxypropanenitrile
- Ethylene cyanohydrin
- 3-Hydroxypropionitrile
- β-Cyanoethanol
- EINECS 203-704-8
- 3-Hydroxypropiononitrile
- Glycol cyanohydrin
3-羟基丙腈物理化学性质
[ 密度 ]:
1.0±0.1 g/cm3
[ 沸点 ]:
229.6±13.0 °C at 760 mmHg
[ 熔点 ]:
-46 °C
[ 分子式 ]:
C3H5NO
[ 分子量 ]:
71.078
[ 闪点 ]:
92.7±19.8 °C
[ 精确质量 ]:
71.037117
[ PSA ]:
44.02000
[ LogP ]:
-0.94
[ 外观性状 ]:
无色或稻黄色的液体
[ 蒸汽密度 ]:
2.5 (vs air)
[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C
[ 折射率 ]:
1.419
[ 储存条件 ]:
库房通风低温干燥,与氧化剂、强酸类、强碱类、食品添加剂分开存放
[ 稳定性 ]:
Stable. Flammable. Incompatible with strong oxidizing agents. Reacts with water or steam to release toxic vapours. Reacts violently with acids, amines, inorganic bases. Corrodes mild steel.
[ 水溶解性 ]:
>=10 g/100 mL at 20 ºC
3-羟基丙腈MSDS
3-羟基丙腈毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- MU5250000
- CHEMICAL NAME :
- Hydracrylonitrile
- CAS REGISTRY NUMBER :
- 109-78-4
- BEILSTEIN REFERENCE NO. :
- 0635773
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 16
- MOLECULAR FORMULA :
- C3-H5-N-O
- MOLECULAR WEIGHT :
- 71.09
- WISWESSER LINE NOTATION :
- Q2CN
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Open irritation test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 26,269,1944
- TYPE OF TEST :
- Open irritation test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 8/18/1967
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,4875,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,4875,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 8,371,1953
- TYPE OF TEST :
- LC33 - Lethal Concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 mg/m3/2H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,66,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 900 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 8,371,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 5 mL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 8/18/1967 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 8100 mg/kg/90D-C
- TOXIC EFFECTS :
- Brain and Coverings - changes in brain weight Cardiac - changes in heart weight
- REFERENCE :
- JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 2,31,1976 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 100 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - E0469 No. of Facilities: 4 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 348 (estimated) No. of Female Employees: 30 (estimated)
3-羟基丙腈安全信息
[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
Xi
[ 风险声明 (欧洲) ]:
R36/37/38
[ 安全声明 (欧洲) ]:
S26-S36-S24/25
[ 危险品运输编码 ]:
2810
[ WGK德国 ]:
1
[ RTECS号 ]:
MU5250000
[ 海关编码 ]:
29269095
3-羟基丙腈合成路线
3-羟基丙腈上下游产品
3-羟基丙腈上游产品
3-羟基丙腈下游产品
3-羟基丙腈制备
由丙烯腈水合而得。另一种制法是由2-氯乙醇与氰化钠反应制得。
精制方法：常压蒸馏时发生分解，应用减压蒸馏精制。
3-羟基丙腈海关
[ 海关编码 ]: 2926909090
[ 中文概述 ]:
2926909090 其他腈基化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
3-羟基丙腈文献
Org. Biomol. Chem. 13(1) , 269-76, (2014)
Chimeric oligonucleotides containing phosphodiester and phosphorothioate linkages have been obtained using the solid phase synthesis. The oligonucleotide parts possessing natural internucleotide phosp...
Identification of two urinary metabolites of rats treated with acrylonitrile; influence of several inhibitors on the mutagenicity of those urines.Toxicol. Lett. 7(4-5) , 321-7, (1981)
Urines collected from rats injected with acrylonitrile (ACN) were mutagenic towards Salmonella typhimurium TA1530; this activity was reduced when the animals were pretreated by pyrazole (inhibitor of ...
Orientation of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine at the surface of formamide and hydroxypropionitrile.Langmuir 26(4) , 2473-6, (2010)
Phospholipids are a main component of cell membranes. Therefore, the experimental investigation of the self-organization of phospholipids is of great interest. Here we present results concerning the o...
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相关化合物
【3-羟基丙腈】化源网提供3-羟基丙腈CAS号109-78-4，3-羟基丙腈MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询3-羟基丙腈上化源网，专业又轻松。>>电脑版：3-羟基丙腈
标题：3-羟基丙腈_MSDS_用途_密度_3-羟基丙腈CAS号【109-78-4】_化源网 地址：https://m.chemsrc.com/mip/cas/109-78-4_28656.html