3,3'-亚胺二丙腈
3,3'-亚胺二丙腈用途
用作气相色谱固定液。
3,3'-亚胺二丙腈名称
[ CAS 号 ]:
111-94-4
[ 中文名 ]:
双(2-氰基乙基)胺
[ 英文名 ]:
Propanenitrile,3,3'-iminobis-
[中文别名 ]:
[英文别名 ]:
- EINECS 203-922-3
- MFCD00001956
- 2341i.s.
- 3,3'-Iminodipropionitrile
- BIS(CYANOETHYL)AMINE
- HN(CH2CH2CN)2
- 3-[(2-cyanoethyl)amino]propanenitrile
- 3,3‘-Iminodipropionitrile
- bis(2-cyanoethyl)amine
- USAF a-8564
3,3'-亚胺二丙腈物理化学性质
[ 密度 ]:
1.02 g/mL at 25 °C(lit.)
[ 沸点 ]:
205 °C25 mm Hg(lit.)
[ 熔点 ]:
-6 °C
[ 分子式 ]:
C6H9N3
[ 分子量 ]:
123.15600
[ 闪点 ]:
>230 °F
[ 精确质量 ]:
123.08000
[ PSA ]:
59.61000
[ LogP ]:
0.79426
[ 外观性状 ]:
透明无色至黄色液体
[ 蒸汽压 ]:
0.00019mmHg at 25°C
[ 折射率 ]:
n20/D 1.47(lit.)
[ 储存条件 ]:
库房通风低温干燥,与食品、氧化剂分开储运,注意包装密封性
[ 稳定性 ]:
Stable, but moisture sensitive. Reaction with moisture may lead to a build up of pressure in sealed bottles. Combustible. Incompatible with strong oxidizing agents.
3,3'-亚胺二丙腈MSDS
3,3'-亚胺二丙腈毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UG2975000
- CHEMICAL NAME :
- Propionitrile, 3,3'-iminodi-
- CAS REGISTRY NUMBER :
- 111-94-4
- BEILSTEIN REFERENCE NO. :
- 1746455
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 18
- MOLECULAR FORMULA :
- C6-H9-N3
- MOLECULAR WEIGHT :
- 123.18
- WISWESSER LINE NOTATION :
- NC2M2CN
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,924,1986
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,924,1986 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2700 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 31,60,1949
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4000 ppm/1H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0522881
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 122,94,1959
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >3200 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555367
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 ug/m3/6H
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555367
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2520 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 10,61,1954
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- >10 mL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0522881 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2800 mg/kg/2W-I
- TOXIC EFFECTS :
- Behavioral - muscle contraction or spasticity Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0522881
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 600 mg/kg/3D-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Ear) - change in acuity Behavioral - changes in motor activity (specific assay) Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 13,575,1991
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1109 mg/kg/3D-I
- TOXIC EFFECTS :
- Spinal Cord - other degenerative changes
- REFERENCE :
- TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 19,622,1991 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 840 mg/kg
- SEX/DURATION :
- female 1-21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
- REFERENCE :
- SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 21,407,1981
3,3'-亚胺二丙腈安全信息
[ 符号 ]:
GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H315-H319-H335
[ 警示性声明 ]:
P261-P305 + P351 + P338
[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
Xi
[ 风险声明 (欧洲) ]:
R36/37/38
[ 安全声明 (欧洲) ]:
S26
[ 危险品运输编码 ]:
UN 3334
[ WGK德国 ]:
2
[ RTECS号 ]:
UG2975000
[ 海关编码 ]:
2926909090
3,3'-亚胺二丙腈合成路线
3,3'-亚胺二丙腈上下游产品
3,3'-亚胺二丙腈上游产品
3,3'-亚胺二丙腈下游产品
3,3'-亚胺二丙腈海关
[ 海关编码 ]: 2926909090
[ 中文概述 ]:
2926909090 其他腈基化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
3,3'-亚胺二丙腈文献
J. Intern. Med. 273(5) , 478-89, (2013)
A number of neurotoxic chemicals induce accumulation of neurofilaments in axonal swellings that appear at varying distances from the cell body. This pathology is associated with axonal degeneration of...
Butenenitriles have low axonopathic potential in the rat.Toxicol. Lett. 200(3) , 187-93, (2011)
IDPN (3,3'-iminodipropionitrile) causes a neurofilamentous proximal axonopathy. This study addressed the hypothesis that the butenenitriles (allylnitrile, cis-crotononitrile and trans-crotononitrile) ...
Behavioral disturbances and hair cell loss in the inner ear following nitrile exposure in mice, guinea pigs, and frogs.Toxicol. Sci. 96(1) , 123-32, (2007)
Several nitriles have been demonstrated to cause hair cell loss in the inner ear of the rat, but the susceptibility of other species to this toxic effect has not been investigated. Adult male Swiss mi...
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