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PRO-ALA-GLU-ASP-LEU-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-ILE-THR-ARG-GLN-ARG-TYR-NH2

用途

Neuropeptide Y (13-36), porcine 是选择性的神经肽 Y2 受体 (neuropeptide Y2 receptor) 的激动剂。

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名称

[ CAS 号 ]:
113662-54-7

[ 中文名 ]:
PRO-ALA-GLU-ASP-LEU-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-ILE-THR-ARG-GLN-ARG-TYR-NH2

[ 英文名 ]:
Neuropeptide Y (13-36) (porcine) trifluoroacetate salt

[中文别名 ]:

神经肽Y(13-36)

[英文别名 ]:

npy 13-36
PAEDLARYYSALRHYINLITRQRY-NH2

生物活性

[ 描述 ]:

Neuropeptide Y (13-36), porcine 是选择性的神经肽 Y2 受体 (neuropeptide Y2 receptor) 的激动剂。

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经肽Y受体

[参考文献]

[1]. Aguirre JA, et al. Centrally injected neuropeptide Y (13-36) produces vasopressor effects and antagonizes the vasodepressor action of neuropeptide Y (1-36) in the awake male rat. Neurosci Lett. 1990 Oct 2;118(1):5-8.

物理化学性质

[ 分子式 ]:
C₁₃₅H₂₀₉N₄₁O₃₆

[ 分子量 ]:
2982.36000

[ 精确质量 ]:
2980.58000

[ PSA ]:
1282.86000

[ LogP ]:
5.51400

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

文献

Regulation of neuropeptide Y release by neuropeptide Y receptor ligands and calcium channel antagonists in hypothalamic slices.

J. Neurochem. 73 , 641-646, (1999)

Neuropeptide Y (NPY) is an important regulator of energy balance in mammals through its orexigenic, antithermogenic, and insulin secretagogue actions. We investigated the regulation of endogenous NPY ...

Neuropeptide Y produces anxiety via Y2-type receptors.

Peptides 19 , 359-363, (1998)

In the present study, the effects of intracerebroventricular (ICV) NPY, [Leu31, Pro34]NPY and NPY13-36 have been evaluated with respect to anxiety in mice in the elevated plus maze. NPY had opposing e...

Evidence for Y1 and Y2 subtypes of neuropeptide Y receptors linked to opposing postjunctional effects observed in rat cardiac myocytes.

Eur. J. Pharmacol. 336 , 257, (1997)

The aim of this study was to confirm the existence of and identify the receptor subtypes for neuropeptide Y that are present post-junctionally in myocardium. The effects of the selective agonists, [Le...

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