阿扎司特
阿扎司特用途
Acitazanolast是一种口服活性抗过敏药物,可抑制组胺释放。Acitazanolast可用于研究IgE抗体引起的I型过敏反应(立即)[1]。
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阿扎司特名称
[ CAS 号 ]:
114607-46-4
[ 中文名 ]:
阿扎司特
[ 英文名 ]:
acitazanolast
[英文别名 ]:
- MTCC
- Oxo((3-(1H-tetrazol-5-yl)phenyl)amino)acetic Acid
- acitazanolast
- Oxo{[3-(2H-tetrazol-5-yl)phenyl]amino}acetic acid
- WP-871
- Acitazanolast,WP-871
阿扎司特生物活性
阿扎司特物理化学性质
[ 密度 ]:
1.7±0.1 g/cm3
[ 分子式 ]:
C9H7N5O3
[ 分子量 ]:
233.184
[ 精确质量 ]:
233.054886
[ PSA ]:
120.86000
[ LogP ]:
0.29
[ 折射率 ]:
1.719
阿扎司特毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AJ1476901
- CHEMICAL NAME :
- Acetic acid, oxo-((3-(1H-tetrazol-5-yl)phenyl)amino)-
- CAS REGISTRY NUMBER :
- 114607-46-4
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C9-H7-N5-O3
- MOLECULAR WEIGHT :
- 233.21
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 49,111,1995
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1927 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression Blood - normocytic anemia
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 49,111,1995
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >1500 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Cardiac - arrhythmias (including changes in conduction) Gastrointestinal - nausea or vomiting
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 49,231,1995 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 22680 mg/kg/28D-C
- TOXIC EFFECTS :
- Liver - changes in liver weight Blood - changes in platelet count Related to Chronic Data - death
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 23,107,1989
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 28 gm/kg/4W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - urine volume increased Kidney, Ureter, Bladder - other changes in urine composition Blood - normocytic anemia
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 49,235,1995
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