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阿扎司特

阿扎司特用途

Acitazanolast是一种口服活性抗过敏药物,可抑制组胺释放。Acitazanolast可用于研究IgE抗体引起的I型过敏反应(立即)[1]。

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阿扎司特名称

[ CAS 号 ]:
114607-46-4

[ 中文名 ]:
阿扎司特

[ 英文名 ]:
acitazanolast

[英文别名 ]:

MTCC
Oxo((3-(1H-tetrazol-5-yl)phenyl)amino)acetic Acid
acitazanolast
Oxo{[3-(2H-tetrazol-5-yl)phenyl]amino}acetic acid
WP-871
Acitazanolast,WP-871

阿扎司特生物活性

[ 描述 ]:

Acitazanolast是一种口服活性抗过敏药物,可抑制组胺释放。Acitazanolast可用于研究IgE抗体引起的I型过敏反应(立即)[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

阿扎司特物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 分子式 ]:
C₉H₇N₅O₃

[ 分子量 ]:
233.184

[ 精确质量 ]:
233.054886

[ PSA ]:
120.86000

[ LogP ]:
0.29

[ 折射率 ]:
1.719

阿扎司特毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AJ1476901

CHEMICAL NAME :: Acetic acid, oxo-((3-(1H-tetrazol-5-yl)phenyl)amino)-

CAS REGISTRY NUMBER :: 114607-46-4

LAST UPDATED :: 199512

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C9-H7-N5-O3

MOLECULAR WEIGHT :: 233.21

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 49,111,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1927 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression Blood - normocytic anemia

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 49,111,1995

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >1500 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Cardiac - arrhythmias (including changes in conduction) Gastrointestinal - nausea or vomiting

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 49,231,1995 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 22680 mg/kg/28D-C

TOXIC EFFECTS :: Liver - changes in liver weight Blood - changes in platelet count Related to Chronic Data - death

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 23,107,1989

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 28 gm/kg/4W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - urine volume increased Kidney, Ureter, Bladder - other changes in urine composition Blood - normocytic anemia

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 49,235,1995