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N-CBZ-L-脯氨酸

N-CBZ-L-脯氨酸用途

碳苯氧基脯氨酸(L-Cbz-脯氨酸)是脯氨酸酶的抑制剂。碳苯氧基脯氨酸可用于脯氨酸酶缺乏症(PD)研究[1]。

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N-CBZ-L-脯氨酸名称

[ CAS 号 ]:
1148-11-4

[ 中文名 ]:
N-苄氧羰基-L-脯氨酸

[ 英文名 ]:
Z-Pro-OH

[中文别名 ]:

[英文别名 ]:

(S)-N-(benzyloxycarbonyl)-proline
Cbz-L-proline
EINECS 214-557-4
(S)-N-CBZ-pyrrolidine-2-carboxylic acid
N-Benzyloxycarbonyl-L-proline
N-Carbobenzyloxy-L-proline
Carbobenzyloxy-L-proline
MFCD00003170
N-Carbobenzoxy-L-proline
(S)-1-carbobenzoxypyrrolidine-2-carboxylic acid

N-CBZ-L-脯氨酸生物活性

[ 描述 ]:

碳苯氧基脯氨酸(L-Cbz-脯氨酸)是脯氨酸酶的抑制剂。碳苯氧基脯氨酸可用于脯氨酸酶缺乏症(PD)研究[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

碳苯氧基脯氨酸(6 mM；0-10 d；pH=6.0)导致线粒体去极化,并使细胞死亡增加33%,据报道,长期培养脯氨酸酶缺乏症(PD)患者的成纤维细胞[1]。碳苯氧基脯氨酸(0,1,3,6mM；1分钟；pH=6.0)导致成纤维细胞脯氨酸酶(FBP)水解,显示出线性竞争抑制[1]。

[体内研究]

碳苯氧基脯氨酸(60 mg/kg；注射；每天一次；3周)作为小鼠模型中红细胞脯氨酸酶的体内抑制剂[1]。动物模型：C57Bl/6J小鼠(4周龄)[1]剂量：60 mg/kg给药：注射；结果：红细胞脯氨酸酶活性显著降低。

N-CBZ-L-脯氨酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
432.3±45.0 °C at 760 mmHg

[ 熔点 ]:
76-78ºC

[ 分子式 ]:
C₁₃H₁₅NO₄

[ 分子量 ]:
249.262

[ 闪点 ]:
215.3±28.7 °C

[ 精确质量 ]:
249.100113

[ PSA ]:
66.84000

[ LogP ]:
1.17

[ 外观性状 ]:
白色至淡黄色晶体粉末

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.582

[ 储存条件 ]:
2~8°C

N-CBZ-L-脯氨酸MSDS

N-CBZ-L-脯氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY0745000

CHEMICAL NAME :: 1,2-Pyrrolidinedicarboxylic acid, 1-benzyl ester, L-

CAS REGISTRY NUMBER :: 1148-11-4

LAST UPDATED :: 199406

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C13-H15-N-O4

MOLECULAR WEIGHT :: 249.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravaginal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 280 mg/kg

SEX/DURATION :: female 28 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravaginal

DOSE :: 280 ug/kg

SEX/DURATION :: female 28 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979

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N-CBZ-L-脯氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R62

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
UY0745000

[ 海关编码 ]:
2933990090

N-CBZ-L-脯氨酸合成路线

N-CBZ-L-脯氨酸上下游产品

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N-CBZ-L-脯氨酸下游产品

N-CBZ-L-脯氨酸海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

N-CBZ-L-脯氨酸文献

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