邻氯苯甲酸

邻氯苯甲酸用途

【用途一】
用作染料中间体及胶水、油漆的防腐剂，也用于制造杀菌剂和医药等
【用途二】
是医药、农药的中间体，主要用于制备氯丙嗪、抗炎灵、双氯灭痛等药物，还用于染料及彩色胶片
【用途三】
邻氯苯甲酸是杀菌剂氟苯嘧啶醇，杀虫剂灭幼脲、杀铃脲，杀螨剂四螨嗪的中间体。
【用途四】
染料、农药、医药的中间体，用于制造氯丙嗪、抗炎灵等药物，用作胶粘剂及涂料的防腐剂及有机合成的原料，还可用于染料及彩色胶片。也可用作杀菌剂。邻氯苯甲酸是碱量法和碘量法的标准试剂。
【用途五】
邻氯苯甲酸是碱量法和碘量法的标准试剂。

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邻氯苯甲酸名称

[ CAS 号 ]:
118-91-2

[ 中文名 ]:
2-氯苯甲酸

[ 英文名 ]:
2-Chlorobenzoic acid

[中文别名 ]:

[英文别名 ]:

o-chlorobenzoic acid
O-CHLORO BENZOIC ACID
Mesalamine Impurity L
Benzoic acid,o-chloro
2-Cba
UNII-8P0867193V
2-chloro-benzoic acid
OCBA
MFCD00002412
2-Chlorobenzoic acid

邻氯苯甲酸物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
275.7±13.0 °C at 760 mmHg

[ 熔点 ]:
138-140 °C(lit.)

[ 分子式 ]:
C₇H₅ClO₂

[ 分子量 ]:
156.566

[ 闪点 ]:
120.5±19.8 °C

[ 精确质量 ]:
155.997803

[ PSA ]:
37.30000

[ LogP ]:
2.04

[ 外观性状 ]:
白色晶体或粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.583

[ 储存条件 ]:
库房低温通风干燥

[ 稳定性 ]:
Stable, combustible. Incompatible with strong bases, strong oxidizing agents.

[ 水溶解性 ]:
soluble in hot water

邻氯苯甲酸MSDS

详细MSDS(安全技术说明书)

邻氯苯甲酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG4976000

CHEMICAL NAME :: Benzoic acid, o-chloro-

CAS REGISTRY NUMBER :: 118-91-2

BEILSTEIN REFERENCE NO. :: 0907340

LAST UPDATED :: 199710

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C7-H5-Cl-O2

MOLECULAR WEIGHT :: 156.57

WISWESSER LINE NOTATION :: QVR BG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,576,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,576,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,18,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 112,53,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83210 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 249 (estimated)

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邻氯苯甲酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
DG4976000

[ 海关编码 ]:
29163900

邻氯苯甲酸合成路线

详细合成路线

邻氯苯甲酸上下游产品

邻氯苯甲酸上游产品

邻氯苯甲酸下游产品

邻氯苯甲酸制备

1. 以苯酐为原料与氢氧化钠和氨水进行酰胺化和降解反应而制得邻氨基苯甲酸，然后用亚硝酸钠，盐酸进行重氮化，再用氯化亚铜，盐酸置换而制得邻氯苯甲酸粗品，经精制后得成品。

3.邻氯甲苯氯化水解制得。

2. 其制备方法有以下两种。
邻氯甲苯氯化水解法
邻氯甲苯置于反应釜中，用紫外灯光照，反应温度100℃，通入氯气进行氯化反应，加深氯化反应深度使生成α，α，α，2-四氯甲苯，或用邻氯甲苯为原料，以偶氮二异丁腈为催化剂进行氯化，亦可得到α，α，α，2-四氯甲苯，然后将上述产物移入水解釜，加入少许酸使其水解生成邻氯苯甲酰氯，水解深度大则可得2-氯苯甲酸。
邻氨基苯甲酸重氮化法
以邻氨基苯甲酸为原料加入盐酸、亚硝酸钠进行重氮化，然后在重氮液中加入Cu₂Cl₂溶于盐酸中的溶液，边加边搅拌，经后处理得邻氯苯甲酸。

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邻氯苯甲酸海关

[ 海关编码 ]: 2916399090

[ 中文概述 ]:
2916399090 其他芳香一元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

邻氯苯甲酸文献

Benzenepolycarboxylic acids with potential anti-hemorrhagic properties and structure–activity relationships

Bioorg. Med. Chem. 19 , 7000-2, (2011)

Previously, we reported the structural requirements of the cinnamic acid relatives for inhibition of snake venom hemorrhagic action. In the present study, we examined the effect of benzenepolycarboxyl...

Pseudomonas aeruginosa 142 uses a three-component ortho-halobenzoate 1,2-dioxygenase for metabolism of 2,4-dichloro- and 2-chlorobenzoate.

J. Bacteriol. 176(11) , 3368-74, (1994)

Cell extracts of Pseudomonas aeruginosa 142, which was previously isolated from a polychlorinated biphenyl-degrading consortium, were shown to degrade 2,4-dichlorobenzoate, 2-chlorobenzoate, and a var...

Complete genome sequence of the haloaromatic acid-degrading bacterium Achromobacter xylosoxidans A8.

J. Bacteriol. 193(3) , 791-2, (2011)

Achromobacter xylosoxidans strain A8 was isolated from soil contaminated with polychlorinated biphenyls. It can use 2-chlorobenzoate and 2,5-dichlorobenzoate as sole sources of carbon and energy. This...

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邻氯苯甲酸

邻氯苯甲酸用途

邻氯苯甲酸名称

邻氯苯甲酸物理化学性质

邻氯苯甲酸MSDS

详细MSDS(安全技术说明书)

邻氯苯甲酸毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

邻氯苯甲酸安全信息

邻氯苯甲酸合成路线

详细合成路线

邻氯苯甲酸上下游产品

邻氯苯甲酸上游产品

邻氯苯甲酸下游产品

邻氯苯甲酸制备

邻氯苯甲酸海关

邻氯苯甲酸文献

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