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洋蓟素

洋蓟素用途

1,4-Dicaffeoylquinic acid (1,4-DCQA) 是从苍耳子中得到的苯丙素类物质,能够抑制 LPS 诱导的 TNF-α 的产生,具有抗炎作用。

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洋蓟素名称

[ CAS 号 ]:
1182-34-9

[ 中文名 ]:
朝鲜蓟提取物

[ 英文名 ]:
Cynarin

[中文别名 ]:

[英文别名 ]:

1,3-DICAFFEOYLQUINIC ACID
1.3-O-Dicaffeoylquinic acid
Indena Cinaran
cin
plemocil
cinarcaf
CINARINE
cynarine
listrocol
cyn

洋蓟素生物活性

[ 描述 ]:

1,4-Dicaffeoylquinic acid (1,4-DCQA) 是从苍耳子中得到的苯丙素类物质,能够抑制 LPS 诱导的 TNF-α 的产生,具有抗炎作用。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. Yoo SR, et al. Phytochemical Analysis on Quantification and the Inhibitory Effects on Inflammatory Responses from the Fruit of Xanthii fructus. Pharmacogn Mag. 2015 Oct;11(Suppl 4):S585-91.

洋蓟素物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
819.9±65.0 °C at 760 mmHg

[ 熔点 ]:
225-227ºC

[ 分子式 ]:
C₂₅H₂₄O₁₂

[ 分子量 ]:
516.45

[ 闪点 ]:
278.1±27.8 °C

[ 精确质量 ]:
516.126770

[ PSA ]:
211.28000

[ LogP ]:
1.99

[ 蒸汽压 ]:
0.0±3.1 mmHg at 25°C

[ 折射率 ]:
1.719

洋蓟素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GD8970000

CHEMICAL NAME :: Cinnamic acid, 3,4-dihydroxy-, 1-carboxy-3,5-dihydroxy-1,4-cyclohexylene ester, hydrate

CAS REGISTRY NUMBER :: 1182-34-9

LAST UPDATED :: 199406

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C25-H24-O12.H2-O

MOLECULAR WEIGHT :: 534.51

WISWESSER LINE NOTATION :: L6TJ AQ BOV1U1R CQ DQ& CQ EVQ EOV1U1R CQ DQ &QH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 117,63,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 117,63,1958

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洋蓟素安全信息

[ 危害码 (欧洲) ]:
Xn;N

[ 风险声明 (欧洲) ]:
R22;R43;R50/53

[ 安全声明 (欧洲) ]:
S36/37-S60-S61

[ 危险品运输编码 ]:
UN 3077

[ 海关编码 ]:
2932999099

洋蓟素海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

洋蓟素