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正十四烷基硫酸钠

正十四烷基硫酸钠用途

十四烷基硫酸钠是一种洗涤剂硬化剂,广泛用于治疗食管静脉曲张和静脉曲张[1]。
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正十四烷基硫酸钠名称

[ CAS 号 ]:
1191-50-0

[ 中文名 ]:
十四烷基磺酸钠

[ 英文名 ]:
Tetradecyl sulfate sodium

[中文别名 ]:

[英文别名 ]:

正十四烷基硫酸钠生物活性

[ 描述 ]:

十四烷基硫酸钠是一种洗涤剂硬化剂,广泛用于治疗食管静脉曲张和静脉曲张[1]。

[ 相关类别 ]:

研究领域 >> 心血管疾病
信号通路 >> 其他 >> 其他

[参考文献]

[1]. Tan KT, et al. Percutaneous sodium tetradecyl sulfate sclerotherapy for peripheral venous vascular malformations: a single-center experience. J Vasc Interv Radiol. 2007;18(3):343-351.

正十四烷基硫酸钠物理化学性质

[ 熔点 ]:
199 °C

[ 分子式 ]:
C14H29NaO4S

[ 分子量 ]:
316.43200

[ 精确质量 ]:
316.16800

[ PSA ]:
74.81000

[ LogP ]:
5.24510

[ 外观性状 ]:
白色固体

[ 储存条件 ]:
室温,密闭,干燥

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

正十四烷基硫酸钠MSDS

正十四烷基硫酸钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XB8660000
CHEMICAL NAME :
1-Tetradecanol, hydrogen sulfate, sodium salt
CAS REGISTRY NUMBER :
1191-50-0
LAST UPDATED :
199710
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C14-H29-O4-S.Na
MOLECULAR WEIGHT :
316.48
WISWESSER LINE NOTATION :
WSQO14 &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
342 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Vascular - regional or general arteriolar or venous dilation
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 42,283,1953
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00154 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intratesticular
DOSE :
400 mg/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 24,884,1973
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
2 mg/kg
SEX/DURATION :
female 14 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 68,257,1983
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravaginal
DOSE :
2500 ug/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 68,257,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82210 No. of Facilities: 740 (estimated) No. of Industries: 12 No. of Occupations: 17 No. of Employees: 4436 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82210 No. of Facilities: 1855 (estimated) No. of Industries: 31 No. of Occupations: 43 No. of Employees: 40158 (estimated) No. of Female Employees: 10922 (estimated)
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正十四烷基硫酸钠安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
XB8660000

[ 海关编码 ]:
2920909090

正十四烷基硫酸钠合成路线

正十四烷基硫酸钠海关

[ 海关编码 ]: 2920909090

[ 中文概述 ]:
2920909090 其他无机酸酯(不包括卤化氢的酯)(包括其盐及它们的卤化,磺化,硝化和亚硝化衍生物)。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2920909090 esters of other inorganic acids of non-metals (excluding esters of hydrogen halides) and their salts; their halogenated, sulphonated, nitrated or nitrosated derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

正十四烷基硫酸钠文献

Wetting effects versus ion pairs diffusivity: interactions of anionic surfactants with highly soluble cationic drugs and its impact on tablet dissolution.

J. Pharm. Sci. 104 , 2255-65, (2015)

A study was conducted to develop a mechanistic understanding of dissolution of a highly soluble cationic drug, metformin hydrochloride, under the influence of anionic surfactants, sodium alkyl sulfate...

An analysis of 72% chromated glycerin used for sclerotherapy: sterility, potency, and cost after extended shelf life.

Dermatol. Surg. 41(1) , 121-5, (2015)

Sclerotherapy is the treatment of reticular veins and telangiectasias of the lower extremities. Sclerosants destroy endothelial tissue and expose subendothelial collagen fibers, which lead to subseque...

The role of amphiphilicity and negative charge in glycoprotein 41 interactions in the hydrophobic pocket.

J. Med. Chem. 52 , 4338-44, (2009)

The hydrophobic pocket within the coiled coil domain of HIV-1 gp41 is considered to be a hot-spot suitable for small molecule intervention of fusion, although so far it has yielded only microM inhibit...


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