VU 0364849

VU 0364849用途

一种有效的,特异性的BMP受体激活素受体样激酶3(ALK3)拮抗剂,Ki为5.4 nM；也抑制ALK6(Ki<1 nM)和ALK2(Ki=42.77 nM),对ALK4/5几乎没有亲和力,BMPR2,AMPK等；在体外和体内阻断SMAD磷酸化,并在部分肝切除术后增强肝再生。

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VU 0364849名称

[ CAS 号 ]:
1206711-14-9

[ 英文名 ]:
VU 0364849

[英文别名 ]:

DMH2
VU0364849

VU 0364849生物活性

[ 描述 ]:

[参考文献]

References 1. Tsugawa D, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):549-58. 2. Langenfeld E, et al. Mol Cancer. 2013 Oct 26;12(1):129. 3. Langenfeld E, et al. PLoS One. 2013 Apr 12;8(4):e61256. View Related Products by Target TGF beta Receptor (TGFBR)

VU 0364849物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 分子式 ]:
C₂₇H₂₅N₅O₂

[ 分子量 ]:
451.520

[ 精确质量 ]:
451.200836

[ LogP ]:
2.09

[ 折射率 ]:
1.689

VU 0364849安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

VU 0364849文献

Small molecule antagonist of the bone morphogenetic protein type I receptors suppresses growth and expression of Id1 and Id3 in lung cancer cells expressing Oct4 or nestin.

Mol. Cancer 12(1) , 129, (2013)

Bone morphogenetic proteins (BMP) are embryonic morphogens that are aberrantly expressed in lung cancer. BMPs mediate cell fate decisions and self-renewal of stem cells, through transcription regulati...

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