邻氯对硝基苯胺
邻氯对硝基苯胺用途
用作有机颜料及分散染料的中间体
【用途二】
用于有机合成，也用作染料中间体
【用途三】
染料和颜料的中间体，主要用于生产颜料银硃R及分散染料红GFL、分散红B等，也用于生产灭钉螺农药。以及用作医药中间体，如制取血防-67糊剂。
邻氯对硝基苯胺名称
[ CAS 号 ]:
121-87-9
[ 中文名 ]:
2-氯-4-硝基苯胺
[ 英文名 ]:
2-Chloro-4-nitroaniline
[中文别名 ]:
[英文别名 ]:
- ocpn
- 2-Chloro-4-nitrobenzenamine
- 2-chloro-4-nitrophenylamine
- 1-Amino-2-chloro-4-nitrobenzene
- o-chloro-nitroaniline
- EINECS 204-502-2
- 4-NITRO-2-CHLOROANILINE
- 2-chloro-4-nitro-aniline
- MFCD00007665
- 2-Chlor-4-nitroanilin
邻氯对硝基苯胺物理化学性质
[ 密度 ]:
1.5±0.1 g/cm3
[ 沸点 ]:
326.2±22.0 °C at 760 mmHg
[ 熔点 ]:
107 °C
[ 分子式 ]:
C6H5ClN2O2
[ 分子量 ]:
172.569
[ 闪点 ]:
151.1±22.3 °C
[ 精确质量 ]:
172.003952
[ PSA ]:
71.84000
[ LogP ]:
2.46
[ 外观性状 ]:
黄色非晶形的粉末
[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C
[ 折射率 ]:
1.646
[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类、食品添加剂分开存放
[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents, strong bases, strong acids.
[ 水溶解性 ]:
0.23 g/L (20 ºC)
邻氯对硝基苯胺MSDS
邻氯对硝基苯胺毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- BX1400000
- CHEMICAL NAME :
- Aniline, 2-chloro-4-nitro-
- CAS REGISTRY NUMBER :
- 121-87-9
- BEILSTEIN REFERENCE NO. :
- 0638657
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C6-H5-Cl-N2-O2
- MOLECULAR WEIGHT :
- 172.58
- WISWESSER LINE NOTATION :
- ZR BG DNW
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6430 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 1800 mg/kg
- TOXIC EFFECTS :
- Behavioral - general anesthetic
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 1 mg/plate
- REFERENCE :
- SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959- Volume(issue)/page/year: 29,34,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0882 No. of Facilities: 708 (estimated) No. of Industries: 12 No. of Occupations: 9 No. of Employees: 2937 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0882 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 737 (estimated)
邻氯对硝基苯胺安全信息
[ 符号 ]:
GHS07, GHS09
[ 信号词 ]:
Warning
[ 危害声明 ]:
H302-H411
[ 警示性声明 ]:
P273
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves
[ 危害码 (欧洲) ]:
Xn:Harmful
[ 风险声明 (欧洲) ]:
R22;R51/53
[ 安全声明 (欧洲) ]:
S22-S24-S61
[ 危险品运输编码 ]:
UN 2237 6.1/PG 3
[ WGK德国 ]:
2
[ RTECS号 ]:
BX1400000
[ 包装等级 ]:
III
[ 危险类别 ]:
6.1(b)
[ 海关编码 ]:
2921420090
邻氯对硝基苯胺合成路线
邻氯对硝基苯胺上下游产品
邻氯对硝基苯胺上游产品
邻氯对硝基苯胺下游产品
邻氯对硝基苯胺制备
1、对硝基苯胺氯化法 对硝基苯胺加盐酸和次氯酸钠进行氯化反应。反应产物经过滤、洗涤、干燥，得成品。原料消耗定额：对硝基苯胺928kg/t、次氯酸钠（10%）5600kg/t、30%盐酸5600kg/t。
2、邻氯对硝基苯酚法经氨化制得。向50ml不锈钢高压釜中加入邻氯对硝基苯酚3.471g（0.02mol）、28%的氨水20g和硫酸铵6.608g（0.05mol），于180℃下反应7h。邻氯对硝基苯酚的转化率为50.9%，邻氯对硝基苯胺的选择性98.2%。
邻氯对硝基苯胺海关
[ 海关编码 ]: 2921420090
[ 中文概述 ]:
2921420090 其他苯胺衍生物及其盐. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
邻氯对硝基苯胺文献
Med. Lav. 82(3) , 253-60, (1991)
The toxicity of 4-chloro-2-nitroaniline (4C2NA) and 2-chloro-4-nitroaniline (2C4NA) was investigated on isolated rat hepatocytes following 1-3 hours of exposure to 0.2 and/or 2 mM of these xenobiotics...
Mutagenic activity of 2-chloro-4-nitroaniline and 5-chlorosalicylic acid in Salmonella typhimurium: two possible metabolites of niclosamide.Mutat. Res. 264(3) , 139-45, (1991)
Niclosamide is an anti-helminthic drug susceptible to being metabolized into a bacterial mutagen by the action of enzymes present in the S9 activation mixture. Additional results from genotoxic studie...
Liquid chromatographic determination of 2-chloro-4-nitroaniline, 2-naphthol, and 2,4-dinitroaniline in D&C red no. 36.J. AOAC Int. 76(2) , 287-91, (1993)
A method is described for the determination of the intermediates and a related impurity in D&C Red No. 36 by reversed-phase liquid chromatography. This method may be used to ensure that limits set for...
相关化工产品/化学物质：
推荐生产厂家/供应商：
公司名：上海化源世纪贸易有限公司
区域：上海市普陀区
价格：
联系人：徐经理
产品详情：2-氯-4-硝基苯胺
公司名：上海吉至生化科技有限公司
区域：上海市奉贤区
价格：
￥148.0/100g
￥需询单/1mg
￥608.0/500g
联系人：刘佳
产品详情：2-氯-4-硝基苯胺
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥451.0/500g
￥59.0/25g
￥197.0/250g
￥需询单/1g
联系人：阿拉丁
产品详情：2-氯-4-硝基苯胺
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相关化合物
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