1,2-二氯-4-硝基苯
1,2-二氯-4-硝基苯用途
1,2-二氯-4-硝基苯名称
[ CAS 号 ]:
99-54-7
[ 中文名 ]:
1,2-二氯-4-硝基苯
[ 英文名 ]:
1,2-Dichloro-4-nitrobenzene
[中文别名 ]:
[英文别名 ]:
- 3,4-Dichloronitrobenzene
- MFCD00007207
- Benzene, 1,2-dichloro-4-nitro-
- 1,2-Dichloro-4-nitrobenzene
- EINECS 202-764-2
1,2-二氯-4-硝基苯物理化学性质
[ 密度 ]:
1.5±0.1 g/cm3
[ 沸点 ]:
255.5±0.0 °C at 760 mmHg
[ 熔点 ]:
39-41 °C(lit.)
[ 分子式 ]:
C6H3Cl2NO2
[ 分子量 ]:
191.999
[ 闪点 ]:
123.9±0.0 °C
[ 精确质量 ]:
190.954086
[ PSA ]:
45.82000
[ LogP ]:
3.16
[ 外观性状 ]:
无色至黄色晶体或米色粉末
[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C
[ 折射率 ]:
1.596
[ 储存条件 ]:
库房通风低温干燥,与氧化剂、食品添加剂分开存放
[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents, strong bases.
[ 水溶解性 ]:
151 mg/L (20 ºC)
[ 凝固点 ]:
30~31℃
1,2-二氯-4-硝基苯MSDS
1,2-二氯-4-硝基苯毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- CZ5250000
- CHEMICAL NAME :
- Benzene, 1,2-dichloro-4-nitro-
- CAS REGISTRY NUMBER :
- 99-54-7
- BEILSTEIN REFERENCE NO. :
- 1818163
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 19
- MOLECULAR FORMULA :
- C6-H3-Cl2-N-O2
- MOLECULAR WEIGHT :
- 192.00
- WISWESSER LINE NOTATION :
- WNR CG DG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 953 mg/kg
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10 gm/m3/4H
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Lungs, Thorax, or Respiration - cyanosis
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1384 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Lungs, Thorax, or Respiration - respiratory depression
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 790 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >200 mg/kg
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10 mg/m3/4H/17W-I
- TOXIC EFFECTS :
- Blood - thrombocytopenia Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 28 mg/m3/4H/21D-I
- TOXIC EFFECTS :
- Blood - eosinophilia Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases
MUTATION DATA
- TEST SYSTEM :
- Insect - Drosophila melanogaster
- DOSE/DURATION :
- 200 ppm
- REFERENCE :
- ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 7,677,1985 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993
1,2-二氯-4-硝基苯安全信息
[ 符号 ]:
GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H302-H317-H319
[ 警示性声明 ]:
P280-P305 + P351 + P338
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ 危害码 (欧洲) ]:
Xn:Harmful;N:Dangerousfortheenvironment;
[ 风险声明 (欧洲) ]:
R22;R36;R51/53
[ 安全声明 (欧洲) ]:
S26-S36/37-S61-S39
[ 危险品运输编码 ]:
2811
[ WGK德国 ]:
3
[ RTECS号 ]:
CZ5250000
[ 包装等级 ]:
III
[ 危险类别 ]:
9
[ 海关编码 ]:
29049085
1,2-二氯-4-硝基苯合成路线
1,2-二氯-4-硝基苯上下游产品
1,2-二氯-4-硝基苯上游产品
1,2-二氯-4-硝基苯下游产品
1,2-二氯-4-硝基苯制备
有两种主要生产方法。一是由邻二氯苯硝化，硝化温度可以控制在0℃左右，也可以在稍高于室温时进行；另一种生产方法是对硝基氯苯氯化。
1,2-二氯-4-硝基苯海关
[ 海关编码 ]: 2904909090
[ 中文概述 ]:
2904909090 其他烃的磺化、硝化、亚硝化衍生物（不论是否卤化）. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
HS:2904909090 sulphonated, nitrated or nitrosated derivatives of hydrocarbons, whether or not halogenated VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
1,2-二氯-4-硝基苯文献
Arch. Toxicol. 78(8) , 477-82, (2004)
Rats were exposed to black tea (2.5% w/v) as their sole drinking liquid for either 1 day or 1 month, while controls were maintained on water. After this treatment period, all animals received a single...
Low glutathione S-transferase dogs.Arch. Toxicol. 78(4) , 218-25, (2004)
Liver and kidney glutathione S-transferase (GST) activities to 1,2-dichloro-4-nitrobenzene (DCNB) as a substrate (GST-D activities) were measured in 280 dogs from five different breeders, and signific...
Mitogen-activated protein kinase p38b interaction with delta class glutathione transferases from the fruit fly, Drosophila melanogaster.J. Insect Sci. 12 , 107, (2012)
Glutathione transferases (GSTs) are a family of multifunctional enzymes involved in xenobiotic biotransformation, drug metabolism, and protection against oxidative damage. The p38b mitogen-activated p...
推荐生产厂家/供应商：
公司名：上海吉至生化科技有限公司
区域：上海市奉贤区
价格：
￥128.0/100g
￥378.0/500g
联系人：刘佳
产品详情：3,4-二氯硝基苯
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥348.0/500g
￥279.0/100g
￥需询单/1g
￥需询单/1g
联系人：阿拉丁李高志
产品详情：3,4-二氯硝基苯
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