间硝基苯甲酸

间硝基苯甲酸用途

【用途一】
用作测定生物碱的试剂等
【用途二】
用作感光材料及医药中间体
【用途三】
该品为感光材料、功能色素、药物的中间体。在医药工业中用来生产胆影酸、醋碘苯酸等。
【用途四】
金属离子沉淀剂。用于生物碱及金属钍测定。有机微量分析测定碳、氢、氮的标准品。中间体制备。

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间硝基苯甲酸名称

[ CAS 号 ]:
121-92-6

[ 中文名 ]:
间硝基苯甲酸

[ 英文名 ]:
3-Nitrobenzoic acid

[中文别名 ]:

[英文别名 ]:

Benzoic acid,m-nitro
m-Nitrobenzoic acid
EINECS 204-508-5
MFCD00007251
m-Nitrobenzenecarboxylic acid
Metanitrobenzoic acid
3-Nitro-benzoic acid
Benzoic acid,3-nitro

间硝基苯甲酸物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
340.7±25.0 °C at 760 mmHg

[ 熔点 ]:
139-141 °C(lit.)

[ 分子式 ]:
C₇H₅NO₄

[ 分子量 ]:
167.119

[ 闪点 ]:
157.5±11.6 °C

[ 精确质量 ]:
167.021851

[ PSA ]:
83.12000

[ LogP ]:
1.82

[ 外观性状 ]:
淡黄色晶体

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.615

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
<0.01 g/100 mL at 18 ºC

间硝基苯甲酸MSDS

间硝基苯甲酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DH5000000

CHEMICAL NAME :: Benzoic acid, m-nitro-

CAS REGISTRY NUMBER :: 121-92-6

BEILSTEIN REFERENCE NO. :: 0908644

LAST UPDATED :: 199701

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C7-H5-N-O4

MOLECULAR WEIGHT :: 167.13

WISWESSER LINE NOTATION :: WNR CVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 670 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - excitement Behavioral - aggression

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 680 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - excitement Behavioral - aggression

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1820 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - excitement Behavioral - aggression

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 610 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - aggression

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 640 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - aggression

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1290 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - aggression

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 11375 mg/kg/13W-C

TOXIC EFFECTS :: Blood - methemoglobinemia-carboxyhemoglobin Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 54600 mg/kg/13W-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

MUTATION DATA

TYPE OF TEST :: DNA repair

TEST SYSTEM :: Bacteria - Bacillus subtilis

DOSE/DURATION :: 500 ug/disc

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 170,11,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6256 No. of Facilities: 389 (estimated) No. of Industries: 7 No. of Occupations: 10 No. of Employees: 4306 (estimated) No. of Female Employees: 1034 (estimated)

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间硝基苯甲酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335-H412

[ 警示性声明 ]:
P261-P273-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R33

[ 安全声明 (欧洲) ]:
S26-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DH5000000

[ 海关编码 ]:
2916399090

间硝基苯甲酸合成路线

间硝基苯甲酸上下游产品

间硝基苯甲酸上游产品

间硝基苯甲酸下游产品

间硝基苯甲酸制备

工业上用苯甲酸为原料，在硫酸存在下用硝酸钠硝化，收率可达60%。若将苯甲酰用甲醇在硫酸存在下酯化成苯甲酸甲酯，再用混酸硝化，然后水解，用这种方法生产稍麻烦，但收率可接近70%。也可用混酸直接硝化而得。收率在60%左右。

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间硝基苯甲酸海关

[ 海关编码 ]: 2916399090

[ 中文概述 ]:
2916399090 其他芳香一元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

间硝基苯甲酸文献

Novel capsaicin analogues as potential anticancer agents: synthesis, biological evaluation, and in silico approach.

Arch. Pharm. (Weinheim) 347(12) , 885-95, (2014)

A novel class of benzo[d][1,3]dioxol-5-ylmethyl alkyl/aryl amide and ester analogues of capsaicin were designed, synthesized, and evaluated for their cytotoxic activity against human and murine cancer...

[Evaluation of the hepatotoxic activity of several chlor-nitro derivatives of benzoic acid].

Vopr. Med. Khim. 29(6) , 113-7, (1983)

Hepatotoxic effects of 4-chloro-3-nitrobenzoic acid (x-NBA), 3-nitrobenzoic acid (NBA) and 4-chlorobenzoic acid (CBA) were studied at the doses corresponding to LD50, 1/10 LD50 and 1/50 LD50. The toxi...

CdSe quantum dots capped PAMAM dendrimer nanocomposites for sensing nitroaromatic compounds.

Talanta 83(5) , 1335-40, (2011)

The detection of nitroaromatic compounds, best known as raw materials in explosives preparations, is important in many fields including environmental science, public security and forensics. CdSe quant...

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间硝基苯甲酸

间硝基苯甲酸用途

间硝基苯甲酸名称

间硝基苯甲酸物理化学性质

间硝基苯甲酸MSDS

详细MSDS(安全技术说明书)

间硝基苯甲酸毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

间硝基苯甲酸安全信息

间硝基苯甲酸合成路线

详细合成路线

间硝基苯甲酸上下游产品

间硝基苯甲酸上游产品

间硝基苯甲酸下游产品

间硝基苯甲酸制备

间硝基苯甲酸海关

间硝基苯甲酸文献

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